National Cancer Institute Thesaurus

Last uploaded: July 29, 2019
Preferred Name

Botulinum Toxin Type A

Synonyms

Onaclostox

BOTULINUM TOXIN TYPE A

Prabotulinumtoxin A

BTX-A

IncobotulinumtoxinA

Botulinum Toxin A

Botox Cosmetic

Xeomin

Botulinum Neurotoxin Type A

Dysport

AbobotulinumtoxinA

onabotulinumtoxinA

DaxibotulinumtoxinA

EvabotulinumtoxinA

Botox

OnabotulinumtoxinA

Botulinum Toxin Type A

Botulinum A Toxin

botulinum toxin A

Definitions

An injectable formulation of a neurotoxin derived through the fermentation of the Hall strain of Clostridium botulinum type A with neuromuscular transmission inhibitory and analgesic activities. Upon injection into the affected muscle, the heavy chain portion of botulinum toxin type A (BTX-A) binds to the cell membrane of the motor nerve and is internalized via endocytosis. Upon entry, the light chain portion of the toxin is activated and cleaves the protein SNAP-25, thereby preventing the fusion of acetylcholine (ACh)-containing synaptic vesicles with the cell membrane and, so, the release of ACh into the neuromuscular junction; subsequent binding of ACH to motor end-plate nicotinic acid receptors and ACh-mediated muscle contraction are thus blocked. In addition to ACh, BTX-A may inhibit the release of neuropeptides, such as substance P and glutamate, which may contribute to its analgesic activity.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C82623

Accepted_Therapeutic_Use_For

Treatment of cervical dystonia, severe primary axillary hyperhidrosis, Glabellar lines, blepharospasm, strabismus

ALT_DEFINITION

A drug used to treat certain medical conditions. These include severe underarm sweating and severe muscle spasms in the neck and shoulders. OnabotulinumtoxinA is also used to smooth wrinkles on the face. It is being studied in the treatment of pain in patients with skin leiomyomas (benign smooth muscle tumors) and other conditions. It is a form of a toxin made by the bacterium Clostridium botulinum..

A toxin made by the bacterium Clostridium botulinum. It can cause food poisoning. The drug Botox is a form of the toxin that can be used in small amounts to treat certain medical conditions. These include severe underarm sweating and severe muscle spasms in the neck and shoulders. Botulinum toxin type A is also used to smooth wrinkles on the face. It is being studied in the treatment of pain in patients with skin leiomyomas (benign smooth muscle tumors) and other conditions.

CAS_Registry

93384-43-1

code

C82623

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

An injectable formulation of a neurotoxin derived through the fermentation of the Hall strain of Clostridium botulinum type A with neuromuscular transmission inhibitory and analgesic activities. Upon injection into the affected muscle, the heavy chain portion of botulinum toxin type A (BTX-A) binds to the cell membrane of the motor nerve and is internalized via endocytosis. Upon entry, the light chain portion of the toxin is activated and cleaves the protein SNAP-25, thereby preventing the fusion of acetylcholine (ACh)-containing synaptic vesicles with the cell membrane and, so, the release of ACh into the neuromuscular junction; subsequent binding of ACH to motor end-plate nicotinic acid receptors and ACh-mediated muscle contraction are thus blocked. In addition to ACh, BTX-A may inhibit the release of neuropeptides, such as substance P and glutamate, which may contribute to its analgesic activity.

Display_Name

Botulinum Toxin Type A

FDA_UNII_Code

E211KPY694

FULL_SYN

Onaclostox

BOTULINUM TOXIN TYPE A

Prabotulinumtoxin A

BTX-A

IncobotulinumtoxinA

Botulinum Toxin A

Botox Cosmetic

Xeomin

Botulinum Neurotoxin Type A

Dysport

AbobotulinumtoxinA

onabotulinumtoxinA

DaxibotulinumtoxinA

EvabotulinumtoxinA

Botox

OnabotulinumtoxinA

Botulinum Toxin Type A

Botulinum A Toxin

botulinum toxin A

label

Botulinum Toxin Type A

Legacy_Concept_Name

Botulinum_Toxin_Type_A

PDQ_Closed_Trial_Search_ID

634923

PDQ_Open_Trial_Search_ID

634923

Preferred_Name

Botulinum Toxin Type A

prefixIRI

ncit:C82623

Semantic_Type

Pharmacologic Substance

Amino Acid, Peptide, or Protein

UMLS_CUI

C0006050

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C296

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Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/MEDLINEPLUS/C0006050 MEDLINEPLUS LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/108890005 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/RXNORM/1712 RXNORM LOOM
http://purl.obolibrary.org/obo/CHEBI_3160 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_3160 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_3160 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_3160 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_3160 CHEBI LOOM
http://purl.obolibrary.org/obo/dinto_DB00083 DINTO LOOM
http://purl.bioontology.org/ontology/VANDF/4020561 VANDF LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148265 NDFRT LOOM
http://www.drugbank.ca/drugs/DB00083 FTC LOOM