National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Cocaine

Synonyms

(1R,2R,3S,5S)-2-Methoxycarbonyltropan-3-yl Benzoate

COCAINE

Cocaine

Definitions

A tropane alkaloid with central nervous systems (CNS) stimulating and local anesthetic activity. Cocaine binds to the dopamine, serotonin, and norepinephrine transport proteins and inhibits the re-uptake of dopamine, serotonin, and norepinephrine into pre-synaptic neurons. This leads to an accumulation of the respective neurotransmitters in the synaptic cleft and may result in increased postsynaptic receptor activation. The mechanism of action through which cocaine exerts its local anesthetic effects is by binding to and blocking the voltage-gated sodium channels in the neuronal cell membrane. By stabilizing neuronal membranes, cocaine inhibits the initiation and conduction of nerve impulses and produces a reversible loss of sensation.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C80153

CAS_Registry

50-36-2

CHEBI_ID

CHEBI:27958

Chemical_Formula

C17H21NO4

code

C80153

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A tropane alkaloid with central nervous systems (CNS) stimulating and local anesthetic activity. Cocaine binds to the dopamine, serotonin, and norepinephrine transport proteins and inhibits the re-uptake of dopamine, serotonin, and norepinephrine into pre-synaptic neurons. This leads to an accumulation of the respective neurotransmitters in the synaptic cleft and may result in increased postsynaptic receptor activation. The mechanism of action through which cocaine exerts its local anesthetic effects is by binding to and blocking the voltage-gated sodium channels in the neuronal cell membrane. By stabilizing neuronal membranes, cocaine inhibits the initiation and conduction of nerve impulses and produces a reversible loss of sensation.

FDA_UNII_Code

I5Y540LHVR

FULL_SYN

(1R,2R,3S,5S)-2-Methoxycarbonyltropan-3-yl Benzoate

COCAINE

Cocaine

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C81016

label

Cocaine

Legacy Concept Name

Cocaine

Preferred_Name

Cocaine

prefixIRI

Thesaurus:C80153

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0009170

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47795

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Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/CHEBI_27958 OBA LOOM
http://purl.obolibrary.org/obo/XCO_0001017 XCO LOOM
http://purl.bioontology.org/ontology/CPT/80353 CPT LOOM
http://purl.obolibrary.org/obo/NCIT_C80153 BERO LOOM
http://purl.bioontology.org/ontology/NDDF/001369 NDDF LOOM
http://purl.bioontology.org/ontology/LNC/LA15257-1 LOINC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.145.074.722.388 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387085005 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/VANDF/4019690 VANDF LOOM
http://purl.obolibrary.org/obo/OMIT_0004352 OMIT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.075.080.875.099.722.388 RH-MESH LOOM
http://purl.bioontology.org/ontology/LNC/MTHU006815 LOINC LOOM
https://go.drugbank.com/drugs/DB00907 MDM LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Cocaine APAONTO LOOM
http://purl.bioontology.org/ontology/MESH/D003042 MESH LOOM
http://purl.bioontology.org/ontology/MEDLINEPLUS/C0009170 MEDLINEPLUS LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D003042 RH-MESH LOOM
http://stirdf.jst.go.jp/id/200907066347001440 IOBC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147782 NDFRT LOOM
http://purl.obolibrary.org/obo/MESH_D003042 BERO LOOM
http://ontriscal#Cocaine ONTRISCAL LOOM
http://purl.bioontology.org/ontology/ATC/S02DA02 ATC LOOM
http://doe-generated-ontology.com/OntoAD#C0009170 ONTOAD LOOM
http://purl.bioontology.org/ontology//12359 METABUS LOOM
http://neuromorpho.org/ontologies/experimentconditionH.owl#NMOOt_604 NMOBR LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.605.869.388 RH-MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/2653 RXNORM LOOM
http://purl.obolibrary.org/obo/CHEBI_23346 NIFSTD LOOM
http://purl.jp/bio/4/id/200906005433373896 IOBC LOOM
http://purl.bioontology.org/ontology/SNMI/C-6B720 SNMI LOOM
http://purl.org/metabus/12359 TESTING_BOSCO LOOM
http://purl.org/metabus/12359 METABUS LOOM
http://purl.obolibrary.org/obo/CHEBI_27958_1 NIFSTD LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#3097 OCHV LOOM
http://purl.bioontology.org/ontology/ATC/N01BC01 ATC LOOM
http://purl.bioontology.org/ontology/ATC/S01HA01 ATC LOOM
http://purl.bioontology.org/ontology/ATC/R02AD03 ATC LOOM
http://www.phoc.org.cn/pmo/class/PMO_00016244 PMAPP-PMO LOOM
http://www.co-ode.org/ontologies/galen#Cocaine GALEN LOOM
http://purl.obolibrary.org/obo/UPa_UPC01416 UPA LOOM
http://purl.obolibrary.org/obo/CHEBI_3801 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_27958 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_27958 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_27958 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_27958 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_27958 NBO LOOM
http://purl.obolibrary.org/obo/CHEBI_27958 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_27958 GSSO LOOM
http://purl.obolibrary.org/obo/CHEBI_27958 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_27958 OBA LOOM
http://purl.obolibrary.org/obo/CHEBI_27958 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_27958 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_27958 GO-PLUS LOOM
http://purl.bioontology.org/ontology/LNC/LP16048-8 LOINC LOOM
http://purl.obolibrary.org/obo/CHEBI_41642 NIFSTD LOOM
http://www.drugbank.ca/drugs/DB00907 FTC LOOM
http://purl.bioontology.org/ontology/CSP/3002-3523 CRISP LOOM
http://neuromorpho.org/ontologies/experimentconditionH.owl#NMOOt_1194 NMOBR LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.132.889.354 RH-MESH LOOM
http://stirdf.jst.go.jp/id/200907099958449697 IOBC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0009170 OCHV LOOM
http://purl.jp/bio/4/id/200906094373402975 IOBC LOOM
http://localhost/plosthes.2017-1#153 PLOSTHES LOOM