National Cancer Institute Thesaurus

Last uploaded: August 27, 2019
Preferred Name

Butoconazole

Synonyms

Butoconazole

BUTOCONAZOLE

RS 35887-10-3

(+-)-1-[4-(4-Chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole

Definitions

A synthetic imidazole derivative with fungistatic properties. Butoconazole interferes with steroid biosynthesis by inhibiting the conversion of lanosterol to ergosterol, thereby changing the fungal cell membrane lipid composition. This alters cell permeability and leads to growth inhibition. Butaconazole nitrate is active against many dermatophytes and yeasts. It also contains antibacterial effects against some gram-positive organisms.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C79927

CAS_Registry

64872-76-0

CHEBI_ID

CHEBI:3240

Chemical_Formula

C19H17Cl3N2S

code

C79927

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A synthetic imidazole derivative with fungistatic properties. Butoconazole interferes with steroid biosynthesis by inhibiting the conversion of lanosterol to ergosterol, thereby changing the fungal cell membrane lipid composition. This alters cell permeability and leads to growth inhibition. Butaconazole nitrate is active against many dermatophytes and yeasts. It also contains antibacterial effects against some gram-positive organisms.

FDA_UNII_Code

0Q771797PH

FULL_SYN

Butoconazole

BUTOCONAZOLE

RS 35887-10-3

(+-)-1-[4-(4-Chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47427

label

Butoconazole

Legacy_Concept_Name

Butoconazole

Preferred_Name

Butoconazole

prefixIRI

ncit:C79927

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0054259

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C514

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http://purl.obolibrary.org/obo/DRON_00017730 DRON LOOM
http://purl.bioontology.org/ontology/RXNORM/19884 RXNORM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C017125 RH-MESH LOOM
http://purl.bioontology.org/ontology/MESH/C017125 MESH LOOM
http://purl.bioontology.org/ontology/NDDF/004962 NDDF LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147742 NDFRT LOOM
http://purl.obolibrary.org/obo/dinto_DB00639 DINTO LOOM
http://purl.bioontology.org/ontology/UATC/G01AF15 ATC LOOM
http://purl.bioontology.org/ontology/VANDF/4019649 VANDF LOOM
http://purl.bioontology.org/ontology/SNMI/C-90A30 SNMI LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372878005 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/CHEBI_3240 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_3240 CHEBI LOOM