National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Preferred Name

Cefadroxil Anhydrous
Synonyms

CEFADROXIL ANHYDROUS

Cefadroxil Anhydrous

(6R,7R)-7-((R)-2-Amino-2-(p-hydroxyphenyl)acetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid

BL-S 578

Oracefal

S-578
Definitions

The anhydrous form of cefadroxil, a semisynthetic first-generation cephalosporin with antibacterial activity. Cefadroxil binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C79562
CAS_Registry

50370-12-2
CHEBI_ID

CHEBI:3479
Chemical_Formula

C16H17N3O5S
code

C79562
Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923
Contributing_Source

FDA
DEFINITION

The anhydrous form of cefadroxil, a semisynthetic first-generation cephalosporin with antibacterial activity. Cefadroxil binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
FDA_UNII_Code

Q525PA8JJB
FULL_SYN

CEFADROXIL ANHYDROUS

Cefadroxil Anhydrous

(6R,7R)-7-((R)-2-Amino-2-(p-hydroxyphenyl)acetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid

BL-S 578

Oracefal

S-578
label

Cefadroxil Anhydrous
Legacy Concept Name

Cefadroxil_Anhydrous
Preferred_Name

Cefadroxil Anhydrous
prefixIRI

Thesaurus:C79562
Semantic_Type

Pharmacologic Substance
UMLS_CUI

C0729015
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C357
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