loading...| Preferred Name |
Pyrimethamine |
|
| Synonyms |
PYRIMETHAMINE Pyrimethamine Daraprim |
|
| Definitions |
A synthetic derivative of ethyl-pyrimidine with potent antimalarial properties. Pyrimethamine is a competitive inhibitor of dihydrofolate reductase (DHFR). DHFR is a key enzyme in the redox cycle for production of tetrahydrofolate, a cofactor that is required for the synthesis of DNA and proteins. This agent is often used in combination with other antimalarials for the treatment of uncomplicated falciparum malaria. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C788 |
|
| CAS_Registry |
58-14-0 |
|
| CHEBI_ID |
CHEBI:8673 |
|
| Chemical_Formula |
C12H13ClN4 |
|
| code |
C788 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA |
|
| DEFINITION |
A synthetic derivative of ethyl-pyrimidine with potent antimalarial properties. Pyrimethamine is a competitive inhibitor of dihydrofolate reductase (DHFR). DHFR is a key enzyme in the redox cycle for production of tetrahydrofolate, a cofactor that is required for the synthesis of DNA and proteins. This agent is often used in combination with other antimalarials for the treatment of uncomplicated falciparum malaria. (NCI04) |
|
| Display_Name |
Pyrimethamine |
|
| FDA_UNII_Code |
Z3614QOX8W |
|
| FULL_SYN |
PYRIMETHAMINE Pyrimethamine Daraprim |
|
| label |
Pyrimethamine |
|
| Legacy Concept Name |
Pyrimethamine |
|
| NCI_Drug_Dictionary_ID |
39578 |
|
| NSC Number |
3061 |
|
| PDQ_Closed_Trial_Search_ID |
39578 |
|
| PDQ_Open_Trial_Search_ID |
39578 |
|
| Preferred_Name |
Pyrimethamine |
|
| prefixIRI |
Thesaurus:C788 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0034283 |
|
| subClassOf |