National Cancer Institute Thesaurus

Last uploaded: August 27, 2019
Preferred Name

Promethazine

Synonyms

Promethazine

PROMETHAZINE

Definitions

A phenothiazine derivative with antiemetic and antihistaminic properties. Promethazine antagonizes the central and peripheral effects of histamine mediated by histamine H1 receptors. The effects include bronchoconstriction, vasodilation and spasmodic contractions of gastrointestinal smooth muscle. In addition, this agent binds to muscarinic receptors, resulting in anticholinergic and antiemetic activities.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C779

CAS_Registry

60-87-7

CHEBI_ID

CHEBI:8461

Chemical_Formula

C17H20N2S

code

C779

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A phenothiazine derivative with antiemetic and antihistaminic properties. Promethazine antagonizes the central and peripheral effects of histamine mediated by histamine H1 receptors. The effects include bronchoconstriction, vasodilation and spasmodic contractions of gastrointestinal smooth muscle. In addition, this agent binds to muscarinic receptors, resulting in anticholinergic and antiemetic activities.

FDA_UNII_Code

FF28EJQ494

FULL_SYN

Promethazine

PROMETHAZINE

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C45907

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97704

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66479

label

Promethazine

Legacy_Concept_Name

Promethazine

NSC_Code

30321

Preferred_Name

Promethazine

prefixIRI

ncit:C779

Semantic_Type

Pharmacologic Substance

Organic Chemical

UMLS_CUI

C0033405

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C740

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http://purl.bioontology.org/ontology/UATC/D04AA10 ATC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.369.670 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D011398 RH-MESH LOOM
http://purl.jp/bio/4/id/200906006637143209 IOBC LOOM
http://www.co-ode.org/ontologies/galen#Promethazine GALEN LOOM
http://purl.bioontology.org/ontology/LNC/LP15006-7 LOINC LOOM
http://purl.obolibrary.org/obo/CHEBI_8461 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_8461 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_8461 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_8461 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_8461 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_8461 MCO LOOM
http://purl.obolibrary.org/obo/CHEBI_8461 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_8461 NIFSTD LOOM
http://purl.bioontology.org/ontology/RCD/X79JO RCD LOOM
http://purl.bioontology.org/ontology/UATC/R06AD02 ATC LOOM
http://www.drugbank.ca/drugs/DB01069 FTC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.494.741.670 RH-MESH LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005754 FASTO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005754 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005754 DMTO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005748 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005748 DMTO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147995 NDFRT LOOM
http://purl.bioontology.org/ontology/MESH/D011398 MESH LOOM
http://purl.bioontology.org/ontology/VANDF/4019910 VANDF LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Promethazine APAONTO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372871004 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/SNMI/C-62820 SNMI LOOM
http://stirdf.jst.go.jp/id/200907048848800824 IOBC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU001492 LOINC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.092.831.690 RH-MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/8745 RXNORM LOOM
http://www.case.edu/EpSO.owl#Promethazine EPSO LOOM