National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Preferred Name

Therapeutic Progesterone
Synonyms

Progestasert

Luteohormone

PROGESTERONE

Corpus luteum hormone

Progestogel

Progesterone

Delta4-pregnene-3,20-dione

17alpha-Hydroxy-6alpha-methylpregn-4-ene-3,20-dione

Syngesterone

Lutocylin M

Therapeutic Progesterone

Corlutina

Corluvite

Cyclogest

Gestiron

Gestone

Lipo-Lutin

Lutocyclin

Lutogyl

Lutromone

Progestin

Progestol

Progeston

Prolidon

Proluton

Utrogestan
Definitions

The therapeutic form of the naturally occurring hormone progesterone. Progesterone binds to the progesterone receptor, resulting in dissociation of heat shock proteins, receptor phosphorylation, and transcription activation through direct or indirect interaction with transcription factors. This agent exerts inhibitory effects on estrogens by decreasing the number of estrogen receptors and increasing its metabolism to inactive metabolites. Progesterone induces secretory changes in the endometrium, decreases uterine contractility during pregnancy, and maintains pregnancy.
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C777
Accepted_Therapeutic_Use_For

Amenorrhea; Functional uterine bleeding; Infertility; Maintenance of pregnancy
CAS_Registry

57-83-0
CHEBI_ID

CHEBI:59826

CHEBI:17026
Chemical_Formula

C21H30O2
code

C777
Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923
Contributing_Source

FDA
DEFINITION

The therapeutic form of the naturally occurring hormone progesterone. Progesterone binds to the progesterone receptor, resulting in dissociation of heat shock proteins, receptor phosphorylation, and transcription activation through direct or indirect interaction with transcription factors. This agent exerts inhibitory effects on estrogens by decreasing the number of estrogen receptors and increasing its metabolism to inactive metabolites. Progesterone induces secretory changes in the endometrium, decreases uterine contractility during pregnancy, and maintains pregnancy.
FDA_UNII_Code

4G7DS2Q64Y
FULL_SYN

Progestasert

Luteohormone

PROGESTERONE

Corpus luteum hormone

Progestogel

Progesterone

Delta4-pregnene-3,20-dione

17alpha-Hydroxy-6alpha-methylpregn-4-ene-3,20-dione

Syngesterone

Lutocylin M

Therapeutic Progesterone

Corlutina

Corluvite

Cyclogest

Gestiron

Gestone

Lipo-Lutin

Lutocyclin

Lutogyl

Lutromone

Progestin

Progestol

Progeston

Prolidon

Proluton

Utrogestan
Is_Related_To_Endogenous_Product

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2297
label

Therapeutic Progesterone
Legacy Concept Name

Therapeutic_Progesterone
NCI_Drug_Dictionary_ID

39059
NSC Number

64377

9704
PDQ_Closed_Trial_Search_ID

39059
PDQ_Open_Trial_Search_ID

39059
Preferred_Name

Therapeutic Progesterone
prefixIRI

Thesaurus:C777
Semantic_Type

Organic Chemical

Pharmacologic Substance
UMLS_CUI

C0591309
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1636
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