loading...| Preferred Name |
Prochlorperazine |
|
| Synonyms |
prochlorperazine 2-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)-phenothiazine PROCHLORPERAZINE Prochlorperazine Compro RP 6140 SKF-4657 |
|
| Definitions |
A synthetic propylpiperazine derivative of phenothiazine with antiemetic, antipsychotic, antihistaminic, and anticholinergic activities. Prochlorperazine antagonizes the dopamine D2-receptor in the chemoreceptor trigger zone (CTZ) of the brain and may prevent chemotherapy-induced emesis. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C774 |
|
| Accepted_Therapeutic_Use_For |
Anxiety; Dizziness; Nausea and vomiting management; Psychosis |
|
| ALT_DEFINITION |
A drug used to prevent or reduce nausea and vomiting. It belongs to the family of drugs called antiemetics. |
|
| CAS_Registry |
58-38-8 |
|
| CHEBI_ID |
CHEBI:8435 |
|
| Chemical_Formula |
C20H24ClN3S |
|
| code |
C774 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 |
|
| Contributing_Source |
CTRP FDA HemOnc |
|
| DEFINITION |
A synthetic propylpiperazine derivative of phenothiazine with antiemetic, antipsychotic, antihistaminic, and anticholinergic activities. Prochlorperazine antagonizes the dopamine D2-receptor in the chemoreceptor trigger zone (CTZ) of the brain and may prevent chemotherapy-induced emesis. (NCI04) |
|
| Display_Name |
Prochlorperazine |
|
| FDA_UNII_Code |
YHP6YLT61T |
|
| FULL_SYN |
prochlorperazine 2-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)-phenothiazine PROCHLORPERAZINE Prochlorperazine Compro RP 6140 SKF-4657 |
|
| Has_Salt_Form | ||
| label |
Prochlorperazine |
|
| Legacy Concept Name |
Prochlorperazine |
|
| NCI_Drug_Dictionary_ID |
39564 |
|
| PDQ_Closed_Trial_Search_ID |
39564 |
|
| PDQ_Open_Trial_Search_ID |
39564 |
|
| Preferred_Name |
Prochlorperazine |
|
| prefixIRI |
Thesaurus:C774 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0033229 |
|
| subClassOf |