National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Probenecid

Synonyms

SK-Probenecid

Benemid

PROB

PROBENECID

Probenecid

probenecid

Definitions

A benzoic acid derivative with antihyperuricemic property. Probenecid competitively inhibits the active reabsorption of urate at the proximal tubule in the kidney thereby increasing urinary excretion of uric acid and lowering serum urate concentrations. This prevents urate deposition and promotes resolution of existing urate deposits. In addition, probenecid modulates the transport of organic acids and acidic drugs at the proximal and distal renal tubule, thereby increasing the drug serum concentration.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C772

ALT_DEFINITION

A drug that is used to treat gout and is used together with some antibiotics to make them work better. It is being studied in the treatment of cancer. It belongs to the family of drugs called antibiotic therapy adjuncts.

CAS_Registry

57-66-9

Chemical_Formula

C13H19NO4S

code

C772

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A benzoic acid derivative with antihyperuricemic property. Probenecid competitively inhibits the active reabsorption of urate at the proximal tubule in the kidney thereby increasing urinary excretion of uric acid and lowering serum urate concentrations. This prevents urate deposition and promotes resolution of existing urate deposits. In addition, probenecid modulates the transport of organic acids and acidic drugs at the proximal and distal renal tubule, thereby increasing the drug serum concentration.

FDA_UNII_Code

PO572Z7917

FULL_SYN

SK-Probenecid

Benemid

PROB

PROBENECID

Probenecid

probenecid

label

Probenecid

Legacy Concept Name

Probenecid

NCI_Drug_Dictionary_ID

40223

NSC Number

18786

PDQ_Closed_Trial_Search_ID

40223

PDQ_Open_Trial_Search_ID

40223

Preferred_Name

Probenecid

prefixIRI

Thesaurus:C772

Semantic_Type

Organic Chemical

Pharmacologic Substance

UMLS_CUI

C0033209

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C921

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Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/XCO_0001206 XCO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0033209 OCHV LOOM
http://purl.obolibrary.org/obo/OMIT_0012295 OMIT LOOM
http://purl.bioontology.org/ontology/LNC/LP16260-9 LOINC LOOM
http://purl.bioontology.org/ontology/RXNORM/8698 RXNORM LOOM
http://www.co-ode.org/ontologies/galen#Probenecid GALEN LOOM
http://stirdf.jst.go.jp/id/200907013057451135 IOBC LOOM
http://purl.bioontology.org/ontology/SNMI/C-72610 SNMI LOOM
http://purl.obolibrary.org/obo/DRON_00014428 ODNAE LOOM
http://purl.obolibrary.org/obo/NCIT_C772 BERO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.065.884.625 RH-MESH LOOM
http://www.phoc.org.cn/pmo/class/PMO_00015959 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/NDDF/002321 NDDF LOOM
http://purl.jp/bio/4/id/200906015026554512 IOBC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU007603 LOINC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#10133 OCHV LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146225 NDFRT LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Probenecid APAONTO LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000040223 PDQ LOOM
http://purl.bioontology.org/ontology/VANDF/4017872 VANDF LOOM
http://www.drugbank.ca/drugs/DB01032 FTC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387365004 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/CSP/2840-3387 CRISP LOOM
http://purl.bioontology.org/ontology/RCD/j63.. RCD LOOM
https://go.drugbank.com/drugs/DB01032 MDM LOOM
http://purl.bioontology.org/ontology/MESH/D011339 MESH LOOM
http://purl.obolibrary.org/obo/MESH_D011339 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_8426 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_8426 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_8426 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_8426 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_8426 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_8426 CHEBI LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D011339 RH-MESH LOOM
http://www.bioassayontology.org/bao#BAO_0000998 BAO LOOM
http://purl.bioontology.org/ontology/ATC/M04AB01 ATC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.590.700.625 RH-MESH LOOM