National Cancer Institute Thesaurus

Last uploaded: August 27, 2019
Preferred Name

Probenecid

Synonyms

PROB

Probenecid

Benemid

probenecid

PROBENECID

SK-Probenecid

Definitions

A benzoic acid derivative with antihyperuricemic property. Probenecid competitively inhibits the active reabsorption of urate at the proximal tubule in the kidney thereby increasing urinary excretion of uric acid and lowering serum urate concentrations. This prevents urate deposition and promotes resolution of existing urate deposits. In addition, probenecid modulates the transport of organic acids and acidic drugs at the proximal and distal renal tubule, thereby increasing the drug serum concentration.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C772

ALT_DEFINITION

A drug that is used to treat gout and is used together with some antibiotics to make them work better. It is being studied in the treatment of cancer. It belongs to the family of drugs called antibiotic therapy adjuncts.

CAS_Registry

57-66-9

Chemical_Formula

C13H19NO4S

code

C772

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A benzoic acid derivative with antihyperuricemic property. Probenecid competitively inhibits the active reabsorption of urate at the proximal tubule in the kidney thereby increasing urinary excretion of uric acid and lowering serum urate concentrations. This prevents urate deposition and promotes resolution of existing urate deposits. In addition, probenecid modulates the transport of organic acids and acidic drugs at the proximal and distal renal tubule, thereby increasing the drug serum concentration.

FDA_UNII_Code

PO572Z7917

FULL_SYN

PROB

Probenecid

Benemid

probenecid

PROBENECID

SK-Probenecid

label

Probenecid

Legacy_Concept_Name

Probenecid

NSC_Code

18786

PDQ_Closed_Trial_Search_ID

40223

PDQ_Open_Trial_Search_ID

40223

Preferred_Name

Probenecid

prefixIRI

ncit:C772

Semantic_Type

Pharmacologic Substance

Organic Chemical

UMLS_CUI

C0033209

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C921

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http://purl.obolibrary.org/obo/DRON_00014428 ODNAE LOOM
http://purl.obolibrary.org/obo/DRON_00014428 DRON LOOM
http://purl.bioontology.org/ontology/CSP/2840-3387 CRISP LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D011339 RH-MESH LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0006102 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0006102 DMTO LOOM
http://www.bioassayontology.org/bao#BAO_0000998 BAO LOOM
http://www.bioassayontology.org/bao#BAO_0000998 BAO LOOM
http://www.co-ode.org/ontologies/galen#Probenecid GALEN LOOM
http://purl.bioontology.org/ontology/MESH/D011339 MESH LOOM
http://purl.bioontology.org/ontology/LNC/LP16260-9 LOINC LOOM
http://www.drugbank.ca/drugs/DB01032 FTC LOOM
http://purl.bioontology.org/ontology/RCD/j63.. RCD LOOM
http://purl.jp/bio/4/id/200906015026554512 IOBC LOOM
http://purl.jp/bio/4/id/200906015026554512 IOBC LOOM
http://purl.jp/bio/4/id/200906015026554512 IOBC LOOM
http://purl.jp/bio/4/id/200906015026554512 IOBC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU007603 LOINC LOOM
http://purl.bioontology.org/ontology/UATC/M04AB01 ATC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387365004 SNOMEDCT LOOM
https://bioportal.bioontology.org/ontologies/FTDM.owl#probenecid FASTO LOOM
http://purl.bioontology.org/ontology/SNMI/C-72610 SNMI LOOM
http://purl.bioontology.org/ontology/RXNORM/8698 RXNORM LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Probenecid APAONTO LOOM
http://purl.bioontology.org/ontology/VANDF/4017872 VANDF LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000040223 PDQ LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.590.700.625 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146225 NDFRT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.065.884.625 RH-MESH LOOM
http://stirdf.jst.go.jp/id/200907013057451135 IOBC LOOM
http://stirdf.jst.go.jp/id/200907013057451135 IOBC LOOM
http://stirdf.jst.go.jp/id/200907013057451135 IOBC LOOM
http://stirdf.jst.go.jp/id/200907013057451135 IOBC LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0006106 FASTO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0006106 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0006106 DMTO LOOM
http://purl.obolibrary.org/obo/CHEBI_8426 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_8426 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_8426 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_8426 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_8426 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_8426 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_8426 CHEBI LOOM