Preferred Name |
Prednisone |
|
Synonyms |
Metacortandracin .delta.1-Cortisone Prednilonga Prednisonum 1,2-Dehydrocortisone 1, 2-Dehydrocortisone Meprosona-F Deltadehydrocortisone Deltacortisone Perrigo Prednisone Prednisone Intensol Delta 1-Cortisone Deltacortene Liquid Pred SK-Prednisone Sk-Prednisone Prednicen-M 17,21-Dihydroxypregna-1,4-diene-3,11,20-trione Predicorten Adasone Cortancyl Dacortin DeCortin Decortisyl Decorton Delta-Dome Deltasone Deltison Deltra Econosone Lisacort Meticorten Ofisolona Orasone PRED PREDNISONE Panafcort Panasol-S Paracort Predeltin Predicor Prednicort Prednidib Predniment Prednisone Prednitone Promifen Rayos Servisone Sterapred prednisone |
|
Definitions |
A synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface receptor attachment and cell entry, prednisone enters the nucleus where it binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of proinflammatory cytokine production. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cell populations. |
|
ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C770 |
|
Accepted_Therapeutic_Use_For |
Inflammatory conditions; Allergic conditions; Hematologic conditions; Neoplastic conditions; Autoimmune conditions; Replacement therapy in adrenal insufficiency |
|
ALT_DEFINITION |
A drug used to lessen inflammation and lower the body's immune response. It is used with other drugs to treat leukemia and lymphoma and other types of cancer. It is also used alone or with other drugs to prevent or treat many other conditions. These include conditions related to cancer, such as anemia (a low level of red blood cells), allergic reactions, and loss of appetite. Prednisone is a type of therapeutic glucocorticoid. |
|
CAS_Registry |
53-03-2 |
|
CHEBI_ID |
CHEBI:8382 |
|
Chemical_Formula |
C21H26O5 |
|
code |
C770 |
|
Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192234 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C183082 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C183083 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186328 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186327 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186341 |
|
Contributing_Source |
CTRP DIPG/DMG FDA GDC HemOnc OORO PCDC |
|
DEFINITION |
A synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface receptor attachment and cell entry, prednisone enters the nucleus where it binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of proinflammatory cytokine production. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cell populations. |
|
Display_Name |
Prednisone |
|
FDA_UNII_Code |
VB0R961HZT |
|
FULL_SYN |
Metacortandracin .delta.1-Cortisone Prednilonga Prednisonum 1,2-Dehydrocortisone 1, 2-Dehydrocortisone Meprosona-F Deltadehydrocortisone Deltacortisone Perrigo Prednisone Prednisone Intensol Delta 1-Cortisone Deltacortene Liquid Pred SK-Prednisone Sk-Prednisone Prednicen-M 17,21-Dihydroxypregna-1,4-diene-3,11,20-trione Predicorten Adasone Cortancyl Dacortin DeCortin Decortisyl Decorton Delta-Dome Deltasone Deltison Deltra Econosone Lisacort Meticorten Ofisolona Orasone PRED PREDNISONE Panafcort Panasol-S Paracort Predeltin Predicor Prednicort Prednidib Predniment Prednisone Prednitone Promifen Rayos Servisone Sterapred prednisone |
|
Is_Value_For_GDC_Property | ||
label |
Prednisone |
|
Legacy Concept Name |
Prednisone |
|
Maps_To |
Prednisone |
|
NCI_Drug_Dictionary_ID |
42487 |
|
NSC Number |
10023 |
|
PDQ_Closed_Trial_Search_ID |
42487 |
|
PDQ_Open_Trial_Search_ID |
42487 |
|
Preferred_Name |
Prednisone |
|
prefixIRI |
Thesaurus:C770 |
|
Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
UMLS_CUI |
C0032952 |
|
subClassOf |