National Cancer Institute Thesaurus

Last uploaded: September 30, 2019
Preferred Name

Prednisolone

Synonyms

Metacortandralone

Kuhlprednon

Meti Derm

Lepi-Cortinolo

Delta-Diona

1,2-Dehydrohydrocortisone

Hostacortin H

Deltasolone

Predni-Helvacort

Deltacortril

Delta- Cortef

Dhasolone

Adnisolone

Klismacort

Decaprednil

Prelone

Delta(1)Hydrocortisone

PREDNISOLONE

Hydeltra

Di-Adreson-F

Pred-Clysma

Dontisolon D

Opredsone

prednisolone

Delta-Cortef

Decortin H

.delta.1-Hydrocortisone

Panafcortelone

Deltidrosol

Frisolona

Cortisolone

Prednicortelone

Gupisone

Delta1-dehydro-hydrocortisone

Predeltilone

Meticortelone

Prednisolonum

Lenisolone

Delta-F

Linola-H-Fett N

Prednisolone

Sterane

Linola-H N

(11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione

Predni-Coelin

Cortalone

Fisopred

Prenilone

Precortisyl

Delta-Phoricol

Dacortin H

Longiprednil

Capsoid

Hydeltrasol

Estilsona

Aprednislon

Deltahydrocortisone

Definitions

A synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface receptor attachment and cell entry, prednisolone enters the nucleus where it binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of proinflammatory cytokine production. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cells populations. (NCI04)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C769

Accepted_Therapeutic_Use_For

Inflammatory conditions; Allergic conditions; Hematologic conditions; Neoplastic conditions; Autoimmune conditions; Replacement therapy in adrenal insufficiency

ALT_DEFINITION

A drug that lessens inflammation and suppresses the body's immune response. It may also kill cancer cells. Prednisolone is used to treat disorders in many organ systems and to treat the symptoms of several types of leukemia and lymphoma. It is also being studied in the treatment of other types of cancer. Prednisolone is a type of therapeutic glucocorticoid.

CAS_Registry

50-24-8

CHEBI_ID

CHEBI:8378

Chemical_Formula

C21H28O5

code

C769

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

A synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface receptor attachment and cell entry, prednisolone enters the nucleus where it binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of proinflammatory cytokine production. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cells populations. (NCI04)

Display_Name

Prednisolone

FDA_UNII_Code

9PHQ9Y1OLM

FULL_SYN

Metacortandralone

Kuhlprednon

Meti Derm

Lepi-Cortinolo

Delta-Diona

1,2-Dehydrohydrocortisone

Hostacortin H

Deltasolone

Predni-Helvacort

Deltacortril

Delta- Cortef

Dhasolone

Adnisolone

Klismacort

Decaprednil

Prelone

Delta(1)Hydrocortisone

PREDNISOLONE

Hydeltra

Di-Adreson-F

Pred-Clysma

Dontisolon D

Opredsone

prednisolone

Delta-Cortef

Decortin H

.delta.1-Hydrocortisone

Panafcortelone

Deltidrosol

Frisolona

Cortisolone

Prednicortelone

Gupisone

Delta1-dehydro-hydrocortisone

Predeltilone

Meticortelone

Prednisolonum

Lenisolone

Delta-F

Linola-H-Fett N

Prednisolone

Sterane

Linola-H N

(11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione

Predni-Coelin

Cortalone

Fisopred

Prenilone

Precortisyl

Delta-Phoricol

Dacortin H

Longiprednil

Capsoid

Hydeltrasol

Estilsona

Aprednislon

Deltahydrocortisone

label

Prednisolone

Legacy_Concept_Name

Prednisolone

NSC_Code

9120

PDQ_Closed_Trial_Search_ID

43296

PDQ_Open_Trial_Search_ID

43296

Preferred_Name

Prednisolone

prefixIRI

ncit:C769

Semantic_Type

Pharmacologic Substance

Organic Chemical

UMLS_CUI

C0032950

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C521

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http://purl.bioontology.org/ontology/NDFRT/N0000146334 NDFRT LOOM
http://purl.bioontology.org/ontology/VANDF/4017988 VANDF LOOM
http://purl.bioontology.org/ontology/UATC/R01AD02 ATC LOOM
http://purl.bioontology.org/ontology/UATC/S01BA04 ATC LOOM
http://www.co-ode.org/ontologies/galen#Prednisolone GALEN LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#10042 OCHV LOOM
http://purl.bioontology.org/ontology/UATC/S03BA02 ATC LOOM
http://purl.jp/bio/4/id/200906036005597987 IOBC LOOM
http://purl.bioontology.org/ontology/RXNORM/8638 RXNORM LOOM
http://purl.bioontology.org/ontology/LNC/MTHU003522 LOINC LOOM
http://webprotege.stanford.edu/RMLTPoYQg83oLCbnC9p0or COPDO LOOM
http://purl.bioontology.org/ontology/UATC/H02AB06 ATC LOOM
http://stirdf.jst.go.jp/id/200907039479477055 IOBC LOOM
http://purl.bioontology.org/ontology/MESH/D011239 MESH LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000043296 PDQ LOOM
http://purl.bioontology.org/ontology/LNC/LP18169-0 LOINC LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Prednisolone APAONTO LOOM
http://purl.bioontology.org/ontology/NDDF/002155 NDDF LOOM
http://purl.bioontology.org/ontology/UATC/C05AA04 ATC LOOM
http://purl.bioontology.org/ontology/UATC/A07EA01 ATC LOOM
http://scai.fraunhofer.de/MSOntology#Prednisolone MSO LOOM
http://purl.obolibrary.org/obo/CHEBI_8378 ODNAE LOOM
http://purl.obolibrary.org/obo/CHEBI_8378 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_8378 CHEBI LOOM
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http://purl.obolibrary.org/obo/CHEBI_8378 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_8378 NIFSTD LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D011239 RH-MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0032950 OCHV LOOM
http://purl.bioontology.org/ontology/UATC/S02BA03 ATC LOOM
http://purl.bioontology.org/ontology/UATC/D07XA02 ATC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/116601002 SNOMEDCT LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000146334 ODAE LOOM
http://purl.bioontology.org/ontology/CSP/0059-8215 CRISP LOOM
http://www.drugbank.ca/drugs/DB00860 FTC LOOM
http://bmi.utah.edu/ontologies/peontology/C0032950 RAO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004532 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004532 DMTO LOOM
http://purl.bioontology.org/ontology/UATC/S01CB02 ATC LOOM
http://purl.bioontology.org/ontology/UATC/D07AA03 ATC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.808.745.432.769.795 RH-MESH LOOM