loading...| Preferred Name |
Ticagrelor |
|
| Synonyms |
Thioxlant-6C AR-C126532XX (1S,2S,3R,5S)-3-(7-((1R,2S)-2-(3,4-Difluorophenyl)cyclopropylamino)-5-(propylthio)-3H-(1,2,3)triazolo(4,5-d)pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol AZD6140 Brilinta Brilique TICAGRELOR Ticagrelor Ticalog |
|
| Definitions |
An orally bioavailable cyclopentyltriazolopyrimidine, with antiplatelet activity. Upon oral administration, ticagrelor and its major metabolite targets and reversibly binds to the platelet adenosine diphosphate (ADP) P2Y12 receptor (P2Y12R) at a site distinct from that of the endogenous agonist ADP. This blocks the platelet signaling pathway, thereby inhibiting the activation of the glycoprotein complex GPIIb/IIIa, fibrinogen binding to platelets and platelet adhesion and aggregation. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C76404 |
|
| Accepted_Therapeutic_Use_For |
Acute Coronary Syndrome |
|
| CAS_Registry |
274693-27-5 |
|
| Chemical_Formula |
C23H28F2N6O4S |
|
| code |
C76404 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 |
|
| Contributing_Source |
CTRP FDA HemOnc |
|
| DEFINITION |
An orally bioavailable cyclopentyltriazolopyrimidine, with antiplatelet activity. Upon oral administration, ticagrelor and its major metabolite targets and reversibly binds to the platelet adenosine diphosphate (ADP) P2Y12 receptor (P2Y12R) at a site distinct from that of the endogenous agonist ADP. This blocks the platelet signaling pathway, thereby inhibiting the activation of the glycoprotein complex GPIIb/IIIa, fibrinogen binding to platelets and platelet adhesion and aggregation. |
|
| Display_Name |
Ticagrelor |
|
| FDA_UNII_Code |
GLH0314RVC |
|
| FULL_SYN |
Thioxlant-6C AR-C126532XX (1S,2S,3R,5S)-3-(7-((1R,2S)-2-(3,4-Difluorophenyl)cyclopropylamino)-5-(propylthio)-3H-(1,2,3)triazolo(4,5-d)pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol AZD6140 Brilinta Brilique TICAGRELOR Ticagrelor Ticalog |
|
| label |
Ticagrelor |
|
| Legacy Concept Name |
Ticagrelor |
|
| Preferred_Name |
Ticagrelor |
|
| prefixIRI |
Thesaurus:C76404 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C1999375 |
|
| subClassOf |