National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Preferred Name

Carbenicillin Indanyl
Synonyms

Carbenicillin Indanyl

CARBENICILLIN INDANYL
Definitions

The indanyl ester of carbenicillin, a broad-spectrum, semisynthetic penicillin derivative with antibacterial activity. Following absorption, carbenicillin indanyl is rapidly hydrolyzed to the active carbenicillin, which binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall, thereby preventing the cross-linkage of peptidoglycans, which are critical components of the bacterial cell wall. This leads to a weakening of the bacterial cell wall, eventually causing bacterial cell lysis.
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C76219
CAS_Registry

35531-88-5
CHEBI_ID

CHEBI:52015
Chemical_Formula

C26H26N2O6S
code

C76219
Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923
Contributing_Source

FDA
DEFINITION

The indanyl ester of carbenicillin, a broad-spectrum, semisynthetic penicillin derivative with antibacterial activity. Following absorption, carbenicillin indanyl is rapidly hydrolyzed to the active carbenicillin, which binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall, thereby preventing the cross-linkage of peptidoglycans, which are critical components of the bacterial cell wall. This leads to a weakening of the bacterial cell wall, eventually causing bacterial cell lysis.
FDA_UNII_Code

5V278481KE
FULL_SYN

Carbenicillin Indanyl

CARBENICILLIN INDANYL
label

Carbenicillin Indanyl
Legacy Concept Name

Carbenicillin_Indanyl
Preferred_Name

Carbenicillin Indanyl
prefixIRI

Thesaurus:C76219
Semantic_Type

Pharmacologic Substance
UMLS_CUI

C0054667
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1500
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