National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Preferred Name

Cephalexin Anhydrous
Synonyms

CEPHALEXIN ANHYDROUS

Cephalexin Anhydrous
Definitions

The anhydrous form of cephalexin, a semisynthetic first-generation cephalosporin with antibacterial activity. Cephalexin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C76180
CAS_Registry

15686-71-2
CHEBI_ID

CHEBI:3534
Chemical_Formula

C16H17N3O4S
code

C76180
Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923
Contributing_Source

FDA
DEFINITION

The anhydrous form of cephalexin, a semisynthetic first-generation cephalosporin with antibacterial activity. Cephalexin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
FDA_UNII_Code

5SFF1W6677
FULL_SYN

CEPHALEXIN ANHYDROUS

Cephalexin Anhydrous
label

Cephalexin Anhydrous
Legacy Concept Name

Cephalexin_Anhydrous
Preferred_Name

Cephalexin Anhydrous
prefixIRI

Thesaurus:C76180
Semantic_Type

Pharmacologic Substance
UMLS_CUI

C2699162
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C357
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