loading...| Preferred Name |
Acenocoumarol |
|
| Synonyms |
ACENOCOUMAROL Acenocoumarol |
|
| Definitions |
A 4-hydroxycoumarin derivative with anticoagulant activity. As a vitamin K antagonist, acenocoumarol inhibits vitamin K epoxide reductase, thereby inhibiting the reduction of vitamin K and the availability of vitamin KH2. This prevents gamma carboxylation of glutamic acid residues near the N-terminals of the vitamin K-dependent clotting factors, including factor II, VII, IX, and X and anticoagulant proteins C and S. This prevents their activity and thus thrombin formation. Compared to other coumarin derivatives, acenocoumarol has a short half-life. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C75152 |
|
| CAS_Registry |
152-72-7 |
|
| CHEBI_ID |
CHEBI:53766 |
|
| Chemical_Formula |
C19H15NO6 |
|
| code |
C75152 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
A 4-hydroxycoumarin derivative with anticoagulant activity. As a vitamin K antagonist, acenocoumarol inhibits vitamin K epoxide reductase, thereby inhibiting the reduction of vitamin K and the availability of vitamin KH2. This prevents gamma carboxylation of glutamic acid residues near the N-terminals of the vitamin K-dependent clotting factors, including factor II, VII, IX, and X and anticoagulant proteins C and S. This prevents their activity and thus thrombin formation. Compared to other coumarin derivatives, acenocoumarol has a short half-life. |
|
| FDA_UNII_Code |
I6WP63U32H |
|
| FULL_SYN |
ACENOCOUMAROL Acenocoumarol |
|
| label |
Acenocoumarol |
|
| Legacy Concept Name |
Acenocoumarol |
|
| NCI_Drug_Dictionary_ID |
750633 |
|
| PDQ_Closed_Trial_Search_ID |
750633 |
|
| PDQ_Open_Trial_Search_ID |
750633 |
|
| Preferred_Name |
Acenocoumarol |
|
| prefixIRI |
Thesaurus:C75152 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0000956 |
|
| subClassOf |