National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Alpha-Tocopherol

Synonyms

Alpha-Tocopherol

3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol

Alpha-tocopherol

.ALPHA.-TOCOPHEROL

2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)chroman-6-ol

Definitions

The orally bioavailable alpha form of the naturally-occurring fat-soluble vitamin E, with potent antioxidant and cytoprotective activities. Upon administration, alpha-tocopherol neutralizes free radicals, thereby protecting tissues and organs from oxidative damage. Alpha-tocopherol gets incorporated into biological membranes, prevents protein oxidation and inhibits lipid peroxidation, thereby maintaining cell membrane integrity and protecting the cell against damage. In addition, alpha-tocopherol inhibits the activity of protein kinase C (PKC) and PKC-mediated pathways. Alpha-tocopherol also modulates the expression of various genes, plays a key role in neurological function, inhibits platelet aggregation and enhances vasodilation. Compared with other forms of tocopherol, alpha-tocopherol is the most biologically active form and is the form that is preferentially absorbed and retained in the body.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C74960

ALT_DEFINITION

Tocopherol with three methyl groups on its chromanol ring.

CAS_Registry

59-02-9

CHEBI_ID

CHEBI:18145

Chemical_Formula

C29H50O2

code

C74960

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

CRCH

CTRP

FDA

DEFINITION

The orally bioavailable alpha form of the naturally-occurring fat-soluble vitamin E, with potent antioxidant and cytoprotective activities. Upon administration, alpha-tocopherol neutralizes free radicals, thereby protecting tissues and organs from oxidative damage. Alpha-tocopherol gets incorporated into biological membranes, prevents protein oxidation and inhibits lipid peroxidation, thereby maintaining cell membrane integrity and protecting the cell against damage. In addition, alpha-tocopherol inhibits the activity of protein kinase C (PKC) and PKC-mediated pathways. Alpha-tocopherol also modulates the expression of various genes, plays a key role in neurological function, inhibits platelet aggregation and enhances vasodilation. Compared with other forms of tocopherol, alpha-tocopherol is the most biologically active form and is the form that is preferentially absorbed and retained in the body.

Display_Name

Alpha-Tocopherol

FDA_UNII_Code

H4N855PNZ1

FULL_SYN

Alpha-Tocopherol

3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol

Alpha-tocopherol

.ALPHA.-TOCOPHEROL

2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)chroman-6-ol

INFOODS

TOCPHA

label

Alpha-Tocopherol

Legacy Concept Name

Alpha-Tocopherol

Macronutrient

Y

NCI_Drug_Dictionary_ID

775583

NCI_META_CUI

CL938214

Nutrient

Y

PDQ_Closed_Trial_Search_ID

775583

PDQ_Open_Trial_Search_ID

775583

Preferred_Name

Alpha-Tocopherol

prefixIRI

Thesaurus:C74960

Semantic_Type

Pharmacologic Substance

Vitamin

Unit

mg

USDA_ID

323

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C68313

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http://purl.obolibrary.org/obo/XCO_0000379 XCO LOOM
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http://sbmi.uth.tmc.edu/ontology/ochv#C0969677 OCHV LOOM
http://purl.obolibrary.org/obo/CHEBI_46430 BIOMODELS LOOM
http://purl.bioontology.org/ontology/MEDLINEPLUS/C0969677 MEDLINEPLUS LOOM
http://purl.obolibrary.org/obo/NCIT_C74960 BERO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D024502 RH-MESH LOOM
http://www.semanticweb.org/ontologies/2018/1/ProstateCancer.owl#Alpha-tocopherol PCAO LOOM
http://purl.bioontology.org/ontology/LNC/LP15369-9 LOINC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/259666007 SNOMEDCT LOOM
https://www.fns-cloud.eu/foodComponents/FNS_H_0000003462 FNS-H LOOM
http://purl.obolibrary.org/obo/CHEBI_22470 EFO LOOM
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http://purl.obolibrary.org/obo/CHEBI_22470 CHEBI LOOM
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http://www.phoc.org.cn/pmo/class/PMO_00017676 PMAPP-PMO LOOM
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http://purl.bioontology.org/ontology/PDQ/CDR0000775583 PDQ LOOM
http://stirdf.jst.go.jp/id/200907037405731488 IOBC LOOM
http://www.ustb.edu.cn/thesauri/tocr/v1/data#C571347974240596057 ACVD_ONTOLOGY LOOM
http://purl.obolibrary.org/obo/CHEBI_18145 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_18145 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_18145 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_18145 DRON LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.150.909.750.249 RH-MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/237099 RXNORM LOOM
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