loading...| Preferred Name |
Dasatinib Anhydrous |
|
| Synonyms |
Dasatinib Anhydrous DASATINIB ANHYDROUS |
|
| Definitions |
An orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib binds to and inhibits the growth-promoting activities of these kinases. Apparently because of its less stringent binding affinity for the BCR-ABL kinase, dasatinib has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations. SRC-family protein-tyrosine kinases interact with variety of cell-surface receptors and participate in intracellular signal transduction pathways; tumorigenic forms can occur through altered regulation or expression of the endogenous protein and by way of virally-encoded kinase genes. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C74556 |
|
| CAS_Registry |
302962-49-8 |
|
| CHEBI_ID |
CHEBI:49375 |
|
| Chemical_Formula |
C22H26ClN7O2S |
|
| code |
C74556 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA |
|
| DEFINITION |
An orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib binds to and inhibits the growth-promoting activities of these kinases. Apparently because of its less stringent binding affinity for the BCR-ABL kinase, dasatinib has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations. SRC-family protein-tyrosine kinases interact with variety of cell-surface receptors and participate in intracellular signal transduction pathways; tumorigenic forms can occur through altered regulation or expression of the endogenous protein and by way of virally-encoded kinase genes. |
|
| Display_Name |
Dasatinib Anhydrous |
|
| FDA_UNII_Code |
X78UG0A0RN |
|
| FULL_SYN |
Dasatinib Anhydrous DASATINIB ANHYDROUS |
|
| Has_Target |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C30164 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16325 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17328 |
|
| label |
Dasatinib Anhydrous |
|
| Legacy Concept Name |
Dasatinib_Anhydrous |
|
| NCI_Drug_Dictionary_ID |
813356 |
|
| Preferred_Name |
Dasatinib Anhydrous |
|
| prefixIRI |
Thesaurus:C74556 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C2699562 |
|
| subClassOf |