National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Phenytoin

Synonyms

Diphenylhydantoin

5,5-Diphenyl-2,4-imidazolidinedione

PHENYTOIN

Phenytoin

Definitions

A hydantoin derivative and a non-sedative antiepileptic agent with anticonvulsant activity. Phenytoin potentially acts by promoting sodium efflux from neurons located in the motor cortex reducing post-tetanic potentiation at synapses. The reduction of potentiation prevents cortical seizure foci spreading to adjacent areas, stabilizing the threshold against hyperexcitability. In addition, this agent appears to reduce sensitivity of muscle spindles to stretch causing muscle relaxation.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C741

Accepted_Therapeutic_Use_For

Epilepsy

CAS_Registry

57-41-0

CHEBI_ID

CHEBI:8107

Chemical_Formula

C15H12N2O2

code

C741

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

HemOnc

DEFINITION

A hydantoin derivative and a non-sedative antiepileptic agent with anticonvulsant activity. Phenytoin potentially acts by promoting sodium efflux from neurons located in the motor cortex reducing post-tetanic potentiation at synapses. The reduction of potentiation prevents cortical seizure foci spreading to adjacent areas, stabilizing the threshold against hyperexcitability. In addition, this agent appears to reduce sensitivity of muscle spindles to stretch causing muscle relaxation.

FDA_UNII_Code

6158TKW0C5

FULL_SYN

Diphenylhydantoin

5,5-Diphenyl-2,4-imidazolidinedione

PHENYTOIN

Phenytoin

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C48011

label

Phenytoin

Legacy Concept Name

Phenytoin

Preferred_Name

Phenytoin

prefixIRI

Thesaurus:C741

Semantic_Type

Organic Chemical

Pharmacologic Substance

UMLS_CUI

C0031507

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C264

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C93038

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Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/CHEBI_8107 OBA LOOM
http://www.case.edu/EpilepsyOntology.owl#Phenytoin EPSO LOOM
http://www.drugbank.ca/drugs/DB00252 FTC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#9622 OCHV LOOM
http://purl.obolibrary.org/obo/CHEBI_8107 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_8107 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_8107 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_8107 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_8107 HOIP LOOM
http://purl.obolibrary.org/obo/CHEBI_8107 DOID LOOM
http://purl.obolibrary.org/obo/CHEBI_8107 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_8107 HHEAR LOOM
http://purl.obolibrary.org/obo/CHEBI_8107 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_8107 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_8107 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_8107 OBA LOOM
http://purl.obolibrary.org/obo/CHEBI_8107 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_8107 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_8107 HINO LOOM
http://purl.obolibrary.org/obo/CHEBI_8107 ODNAE LOOM
http://purl.obolibrary.org/obo/NCIT_C741 BERO LOOM
http://www.gamuts.net/entity#phenytoin GAMUTS LOOM
http://scai.fraunhofer.de/MSOntology#phenytoin MSO LOOM
http://purl.bioontology.org/ontology/VANDF/4017856 VANDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D010672 RH-MESH LOOM
http://www.case.edu/EpSO.owl#Phenytoin MEPO LOOM
http://www.semanticweb.org/dellvostro3750/ontologies/2018/2/untitled-ontology-10#phenytoin HP_O LOOM
http://stirdf.jst.go.jp/id/200907036802684511 IOBC LOOM
http://purl.bioontology.org/ontology/MESH/D010672 MESH LOOM
http://bmi.utah.edu/ontologies/hfontology/C0031507 HFO LOOM
http://purl.bioontology.org/ontology/SNMI/C-61640 SNMI LOOM
http://www.semanticweb.org/ftuha/ontologies/2021/5/FRMO-01untitled-ontology-175/Phenytoin FRMO LOOM
http://purl.obolibrary.org/obo/OMIT_0011660 OMIT LOOM
http://www.co-ode.org/ontologies/galen#Phenytoin GALEN LOOM
http://purl.bioontology.org/ontology/CSP/1548-7299 CRISP LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.129.308.432.555.730 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387220006 SNOMEDCT LOOM
http://www.phoc.org.cn/pmo/class/PMO_00018190 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/LNC/LP14732-9 LOINC LOOM
http://purl.bioontology.org/ontology/RXNORM/8183 RXNORM LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000146211 ODAE LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000146211 OCVDAE LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0031507 OCHV LOOM
http://purl.obolibrary.org/obo/MESH_D010672 BERO LOOM
http://purl.jp/bio/4/id/200906028151591025 IOBC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU002993 LOINC LOOM
http://scai.fraunhofer.de/MSOntology#Phenytoin MSO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146211 NDFRT LOOM
http://purl.bioontology.org/ontology/ATC/N03AB02 ATC LOOM
https://go.drugbank.com/drugs/DB00252 MDM LOOM
http://purl.bioontology.org/ontology/CPT/1011174 CPT LOOM
https://bioportal.bioontology.org/ontologies/STMSO#Phenytoin STMSO LOOM