loading...| Preferred Name |
Phenothiazine |
|
| Synonyms |
PHENOTHIAZINE Phenothiazine phenothiazine |
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| Definitions |
A class of agents exhibiting antiemetic, antipsychotic, antihistaminic, and anticholinergic activities. Phenothiazines antagonize the dopamine D2-receptor in the chemoreceptor trigger zone (CTZ) of the brain, potentially preventing chemotherapy-induced emesis. In addition, these agents have peripherally or centrally antagonistic activity against alpha adrenergic, serotonergic, histaminic, and muscarinic receptors. (NCI) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C740 |
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| ALT_DEFINITION |
A type of drug that is used to treat severe mental and emotional disorders, severe nausea and vomiting, and certain other conditions. It belongs to the families of drugs called antipsychotics and antiemetics. |
|
| CAS_Registry |
92-84-2 |
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| CHEBI_ID |
CHEBI:38093 CHEBI:37931 |
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| Chemical_Formula |
C12H9NS |
|
| code |
C740 |
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| Concept_In_Subset | ||
| Contributing_Source |
FDA |
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| DEFINITION |
A class of agents exhibiting antiemetic, antipsychotic, antihistaminic, and anticholinergic activities. Phenothiazines antagonize the dopamine D2-receptor in the chemoreceptor trigger zone (CTZ) of the brain, potentially preventing chemotherapy-induced emesis. In addition, these agents have peripherally or centrally antagonistic activity against alpha adrenergic, serotonergic, histaminic, and muscarinic receptors. (NCI) |
|
| FDA_UNII_Code |
GS9EX7QNU6 |
|
| FULL_SYN |
PHENOTHIAZINE Phenothiazine phenothiazine |
|
| label |
Phenothiazine |
|
| Legacy Concept Name |
Phenothiazine |
|
| Preferred_Name |
Phenothiazine |
|
| prefixIRI |
Thesaurus:C740 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0031436 |
|
| subClassOf |