National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Phenobarbital

Synonyms

Phenobarbital

phenobarbital

5-Ethyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione

PHENOBARBITAL

PHENO

Definitions

A long-acting barbituric acid derivative with antipsychotic property. Phenobarbital binds to and activates the gamma-aminobutyric acid (GABA)-A receptor, thereby mimicking the inhibitory actions of GABA in the brain. The activation effects of the phenobarbital-receptor-ionophore complex include increased frequency of chloride channel openings, membrane hyperpolarization and ultimately synaptic inhibition and decreased neuronal excitability. In addition, this agent inhibits glutamate induced depolarization.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C739

Accepted_Therapeutic_Use_For

Epilepsy

ALT_DEFINITION

A drug that is used to treat seizures and as a sedative. It is being studied in the treatment of diarrhea and for its ability to increase the antitumor effect of other therapies. It belongs to the family of drugs called barbiturates.

CAS_Registry

50-06-6

CHEBI_ID

CHEBI:8069

Chemical_Formula

C12H12N2O3

code

C739

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A long-acting barbituric acid derivative with antipsychotic property. Phenobarbital binds to and activates the gamma-aminobutyric acid (GABA)-A receptor, thereby mimicking the inhibitory actions of GABA in the brain. The activation effects of the phenobarbital-receptor-ionophore complex include increased frequency of chloride channel openings, membrane hyperpolarization and ultimately synaptic inhibition and decreased neuronal excitability. In addition, this agent inhibits glutamate induced depolarization.

FDA_UNII_Code

YQE403BP4D

FULL_SYN

Phenobarbital

phenobarbital

5-Ethyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione

PHENOBARBITAL

PHENO

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C76956

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C95059

label

Phenobarbital

Legacy Concept Name

Phenobarbital

NCI_Drug_Dictionary_ID

42405

NSC Number

128143

9848

PDQ_Closed_Trial_Search_ID

42405

PDQ_Open_Trial_Search_ID

42405

Preferred_Name

Phenobarbital

prefixIRI

Thesaurus:C739

Semantic_Type

Organic Chemical

Pharmacologic Substance

UMLS_CUI

C0031412

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C264

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C67084

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Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/XCO_0001203 XCO LOOM
http://www.case.edu/EpilepsyOntology.owl#Phenobarbital EPSO LOOM
http://purl.bioontology.org/ontology/RXNORM/8134 RXNORM LOOM
http://www.gamuts.net/entity#phenobarbital GAMUTS LOOM
http://www.case.edu/EpSO.owl#Phenobarbital MEPO LOOM
http://purl.bioontology.org/ontology/CPT/80184 CPT LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass76d85774_6873_492b_9f37_09bcdb4cce7b WWECA LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClassbfa7f9a0_dd19_4e74_8927_3da690b16ab9 WWECA LOOM
http://purl.jp/bio/4/id/200906049799167030 IOBC LOOM
http://purl.bioontology.org/ontology/VANDF/4017422 VANDF LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Phenobarbital APAONTO LOOM
http://purl.obolibrary.org/obo/CHEBI_8069 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_8069 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_8069 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_8069 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_8069 HOIP LOOM
http://purl.obolibrary.org/obo/CHEBI_8069 DOID LOOM
http://purl.obolibrary.org/obo/CHEBI_8069 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_8069 HHEAR LOOM
http://purl.obolibrary.org/obo/CHEBI_8069 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_8069 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_8069 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_8069 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_8069 NIFSTD LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0031412 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D010634 RH-MESH LOOM
https://go.drugbank.com/drugs/DB01174 MDM LOOM
http://www.semanticweb.org/rjyy/ontologies/2015/5/ESSO#Phenobarbital ESSO LOOM
http://www.semanticweb.org/rjyy/ontologies/2015/5/ESSO#Phenobarbital MEPO LOOM
http://purl.obolibrary.org/obo/NCIT_C739 BERO LOOM
http://purl.obolibrary.org/obo/MESH_D010634 BERO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/373505007 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/LNC/MTHU066205 LOINC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#9598 OCHV LOOM
http://purl.bioontology.org/ontology/LNC/LP14729-5 LOINC LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClasscb7a89af_955f_4b5d_a48a_77e66e590119 WWECA LOOM
http://www.drugbank.ca/drugs/DB01174 FTC LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000042405 PDQ LOOM
http://www.projecthalo.com/aura#Phenobarbital AURA LOOM
http://www.phoc.org.cn/pmo/class/PMO_00018447 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/SNMI/C-61320 SNMI LOOM
http://purl.bioontology.org/ontology/LNC/LA28622-1 LOINC LOOM
http://purl.bioontology.org/ontology/MESH/D010634 MESH LOOM
http://purl.bioontology.org/ontology/ATC/N03AA02 ATC LOOM
http://stirdf.jst.go.jp/id/200907090523280154 IOBC LOOM
http://purl.obolibrary.org/obo/OMIT_0011623 OMIT LOOM
http://www.semanticweb.org/ftuha/ontologies/2021/5/FRMO-01untitled-ontology-175/Phenobarbital FRMO LOOM
http://purl.bioontology.org/ontology/LNC/MTHU060452 LOINC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000145810 NDFRT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.742.698.253.650 RH-MESH LOOM
http://purl.bioontology.org/ontology/CSP/2517-5803 CRISP LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClassdb8cba67_a0ea_4eb7_8881_c253380c2609 WWECA LOOM