loading...| Preferred Name |
Varenicline |
|
| Synonyms |
7,8,9,10-tetrahydro-6,10-methano-6H-pyrazino(2,3-h)(3)benzazepine (2R,3R)-2,3-dihydroxybutqanedioate Varenicline VARENICLINE CP-526555 Champix Chantix |
|
| Definitions |
A partial agonist of the nicotinic acetylcholine receptor (nAChR) subtype alpha4beta2. Nicotine stimulation of central alpha4beta2 nAChRs located at presynaptic terminals in the nucleus accumbens causes the release of the neurotransmitter dopamine, which may be associated with the experience of pleasure; nicotine addiction constitutes a physiologic dependence related to this dopaminergic reward system. As an AChR partial agonist, varenicline attenuates the craving and withdrawal symptoms that occur with abstinence from nicotine but is not habit-forming itself. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C73609 |
|
| ALT_DEFINITION |
A drug used to help people stop smoking by acting the same way nicotine acts in the brain. It is a type of nicotine receptor partial agonist. |
|
| CAS_Registry |
249296-44-4 |
|
| Chemical_Formula |
C13H13N3 |
|
| code |
C73609 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA |
|
| DEFINITION |
A partial agonist of the nicotinic acetylcholine receptor (nAChR) subtype alpha4beta2. Nicotine stimulation of central alpha4beta2 nAChRs located at presynaptic terminals in the nucleus accumbens causes the release of the neurotransmitter dopamine, which may be associated with the experience of pleasure; nicotine addiction constitutes a physiologic dependence related to this dopaminergic reward system. As an AChR partial agonist, varenicline attenuates the craving and withdrawal symptoms that occur with abstinence from nicotine but is not habit-forming itself. |
|
| Display_Name |
Varenicline |
|
| FDA_UNII_Code |
W6HS99O8ZO |
|
| FULL_SYN |
7,8,9,10-tetrahydro-6,10-methano-6H-pyrazino(2,3-h)(3)benzazepine (2R,3R)-2,3-dihydroxybutqanedioate Varenicline VARENICLINE CP-526555 Champix Chantix |
|
| Has_Salt_Form | ||
| label |
Varenicline |
|
| Legacy Concept Name |
Varenicline |
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| NCI_Drug_Dictionary_ID |
584706 |
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| PDQ_Closed_Trial_Search_ID |
584706 |
|
| PDQ_Open_Trial_Search_ID |
584706 |
|
| Preferred_Name |
Varenicline |
|
| prefixIRI |
Thesaurus:C73609 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C1569608 |
|
| subClassOf |