National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Pentamidine

Synonyms

Aerosolized Pentamadine

PENTAMIDINE

Pentamidine

pentamidine

Definitions

A synthetic derivative of amidine with antiprotozoal and antifungal activities. Although the precise mode of action of pentamidine is unclear, it appears to interact directly with the pathogen genome by binding to AT-rich regions of duplex DNA and the minor groove of DNA, thereby interfering with DNA replication. (NCI04)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C731

ALT_DEFINITION

The active ingredient in a drug used to treat infections caused by certain microorganisms. It is also being studied in the treatment of melanoma. It prevents DNA from being copied and may kill cancer cells. It is a type of antifungal agent, a type of antiprotozoal agent, and a type of PRL phosphatase inhibitor.

CAS_Registry

100-33-4

CHEBI_ID

CHEBI:45081

Chemical_Formula

C19H24N4O2

code

C731

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

CTRP

FDA

HemOnc

DEFINITION

A synthetic derivative of amidine with antiprotozoal and antifungal activities. Although the precise mode of action of pentamidine is unclear, it appears to interact directly with the pathogen genome by binding to AT-rich regions of duplex DNA and the minor groove of DNA, thereby interfering with DNA replication. (NCI04)

Display_Name

Pentamidine

FDA_UNII_Code

673LC5J4LQ

FULL_SYN

Aerosolized Pentamadine

PENTAMIDINE

Pentamidine

pentamidine

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29349

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C200703

label

Pentamidine

Legacy Concept Name

Pentamidine

NCI_Drug_Dictionary_ID

40324

NSC Number

9921

PDQ_Closed_Trial_Search_ID

40324

PDQ_Open_Trial_Search_ID

40324

Preferred_Name

Pentamidine

prefixIRI

Thesaurus:C731

Semantic_Type

Organic Chemical

Pharmacologic Substance

Antibiotic

UMLS_CUI

C0030863

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C277

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C514

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Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/SNMI/C-52050 SNMI LOOM
http://purl.obolibrary.org/obo/OMIT_0011413 OMIT LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000040324 PDQ LOOM
http://purl.jp/bio/4/id/200906001301045800 IOBC LOOM
http://purl.obolibrary.org/obo/ARO_3007314 ARO LOOM
http://purl.obolibrary.org/obo/CHEBI_45081 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_45081 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_45081 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_45081 COVID-19 LOOM
http://purl.obolibrary.org/obo/CHEBI_45081 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_45081 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_45081 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_45081 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_45081 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_45081 PHIPO LOOM
http://purl.obolibrary.org/obo/CHEBI_45081 ODNAE LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0030863 OCHV LOOM
http://purl.bioontology.org/ontology/VANDF/4019881 VANDF LOOM
http://www.drugbank.ca/drugs/DB00738 FTC LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000147966 ODAE LOOM
https://go.drugbank.com/drugs/DB00738 MDM LOOM
http://purl.bioontology.org/ontology/RXNORM/7994 RXNORM LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147966 NDFRT LOOM
http://purl.bioontology.org/ontology/CSP/0114-0900 CRISP LOOM
http://purl.bioontology.org/ontology/MESH/D010419 MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D010419 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372699006 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/NCIT_C731 BERO LOOM
http://purl.obolibrary.org/obo/MESH_D010419 BERO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.078.100.700 RH-MESH LOOM
http://purl.bioontology.org/ontology/RCD/x01JH RCD LOOM
http://www.phoc.org.cn/pmo/class/PMO_00015994 PMAPP-PMO LOOM
http://stirdf.jst.go.jp/id/200907024698542981 IOBC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#9436 OCHV LOOM