National Cancer Institute Thesaurus

Last uploaded: July 29, 2019
Preferred Name

Pentamidine

Synonyms

pentamidine

Aerosolized Pentamadine

PENTAMIDINE

Pentamidine

Definitions

A synthetic derivative of amidine with antiprotozoal and antifungal activities. Although the precise mode of action of pentamidine is unclear, it appears to interact directly with the pathogen genome by binding to AT-rich regions of duplex DNA and the minor groove of DNA, thereby interfering with DNA replication. (NCI04)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C731

ALT_DEFINITION

The active ingredient in a drug used to treat infections caused by certain microorganisms. It is also being studied in the treatment of melanoma. It prevents DNA from being copied and may kill cancer cells. It is a type of antifungal agent, a type of antiprotozoal agent, and a type of PRL phosphatase inhibitor.

CAS_Registry

100-33-4

CHEBI_ID

CHEBI:45081

Chemical_Formula

C19H24N4O2

code

C731

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

A synthetic derivative of amidine with antiprotozoal and antifungal activities. Although the precise mode of action of pentamidine is unclear, it appears to interact directly with the pathogen genome by binding to AT-rich regions of duplex DNA and the minor groove of DNA, thereby interfering with DNA replication. (NCI04)

Display_Name

Pentamidine

FDA_UNII_Code

673LC5J4LQ

FULL_SYN

pentamidine

Aerosolized Pentamadine

PENTAMIDINE

Pentamidine

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29349

label

Pentamidine

Legacy_Concept_Name

Pentamidine

NSC_Code

9921

PDQ_Closed_Trial_Search_ID

40324

PDQ_Open_Trial_Search_ID

40324

Preferred_Name

Pentamidine

prefixIRI

ncit:C731

Semantic_Type

Organic Chemical

Antibiotic

UMLS_CUI

C0030863

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C514

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C277

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http://www.drugbank.ca/drugs/DB00738 FTC LOOM