National Cancer Institute Thesaurus

Last uploaded: October 28, 2019
Preferred Name

Tigecycline

Synonyms

Tigecycline

TIGECYCLINE

Tygacil

Definitions

A broad-spectrum glycylcycline antibiotic derived from tetracycline. Tigecycline binds to the 30S ribosomal subunit, thereby interfering with the binding of aminoacyl-tRNA to the mRNA-ribosome complex. This prevents the incorporation of amino acid residues into the elongating peptide chain, inhibiting protein synthesis and eventually bacterial cell growth.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C72865

Accepted_Therapeutic_Use_For

Community-Acquired Bacterial Pneumonia

CAS_Registry

220620-09-7

CHEBI_ID

CHEBI:149836

Chemical_Formula

C29H39N5O8

code

C72865

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A broad-spectrum glycylcycline antibiotic derived from tetracycline. Tigecycline binds to the 30S ribosomal subunit, thereby interfering with the binding of aminoacyl-tRNA to the mRNA-ribosome complex. This prevents the incorporation of amino acid residues into the elongating peptide chain, inhibiting protein synthesis and eventually bacterial cell growth.

FDA_UNII_Code

70JE2N95KR

FULL_SYN

Tigecycline

TIGECYCLINE

Tygacil

label

Tigecycline

Legacy_Concept_Name

Tigecycline

Preferred_Name

Tigecycline

prefixIRI

ncit:C72865

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C1260298

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C258

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