National Cancer Institute Thesaurus

Last uploaded: November 25, 2019
Preferred Name

Cefditoren

Synonyms

CEFDITOREN

Cefditoren

Definitions

A semisynthetic, broad-spectrum, beta-lactamase-resistant, third-generation cephalosporin with antibacterial activity. Cefditoren binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C72625

CAS_Registry

104145-95-1

CHEBI_ID

CHEBI:59343

Chemical_Formula

C19H18N6O5S3

code

C72625

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A semisynthetic, broad-spectrum, beta-lactamase-resistant, third-generation cephalosporin with antibacterial activity. Cefditoren binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.

FDA_UNII_Code

81QS09V3YW

FULL_SYN

CEFDITOREN

Cefditoren

label

Cefditoren

Legacy_Concept_Name

Cefditoren

Preferred_Name

Cefditoren

prefixIRI

ncit:C72625

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0287573

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C357

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http://purl.obolibrary.org/obo/ARO_3000649 ARO LOOM
http://purl.bioontology.org/ontology/MESH/C073460 MESH LOOM
http://purl.jp/bio/4/id/200906067639128915 IOBC LOOM
http://purl.obolibrary.org/obo/CHEBI_59343 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_59343 GENEPIO LOOM
http://purl.obolibrary.org/obo/CHEBI_59343 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_59343 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_59343 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_59343 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_59343 GENEPIO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/708598002 SNOMEDCT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#27745 OCHV LOOM
http://purl.bioontology.org/ontology/LNC/MTHU016669 LOINC LOOM
http://purl.bioontology.org/ontology/LNC/LP33348-1 LOINC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0287573 OCHV LOOM
http://purl.bioontology.org/ontology/NDDF/009507 NDDF LOOM
http://purl.bioontology.org/ontology/RXNORM/83682 RXNORM LOOM
http://stirdf.jst.go.jp/id/200907015204427299 IOBC LOOM
http://purl.bioontology.org/ontology/VANDF/4024247 VANDF LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000022252 NDFRT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C073460 RH-MESH LOOM
http://purl.bioontology.org/ontology/UATC/J01DD16 ATC LOOM