National Cancer Institute Thesaurus

Last uploaded: November 25, 2019
Preferred Name

Papaverine

Synonyms

Papaverine

Pavabid

Pavacap

PAPAVERINE

Cerespan

Robaxapap

Pavatym

Cerebid

Definitions

An opiate alkaloid isolated from the plant Papaver somniferum and produced synthetically. As a direct-acting smooth muscle relaxant, papaverine is not closely related to the other opium alkaloids in structure or pharmacological actions; its mechanism of action may involve the non-selective inhibition of phosphodiesterases and direct inhibition of calcium channels. This agent also exhibits antiviral activity against respiratory syncytial virus, cytomegalovirus, and HIV. (NCI04)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C726

Accepted_Therapeutic_Use_For

Ischemia, cerebral and peripheral

CAS_Registry

58-74-2

CHEBI_ID

CHEBI:28241

Chemical_Formula

C20H21NO4

code

C726

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

An opiate alkaloid isolated from the plant Papaver somniferum and produced synthetically. As a direct-acting smooth muscle relaxant, papaverine is not closely related to the other opium alkaloids in structure or pharmacological actions; its mechanism of action may involve the non-selective inhibition of phosphodiesterases and direct inhibition of calcium channels. This agent also exhibits antiviral activity against respiratory syncytial virus, cytomegalovirus, and HIV. (NCI04)

Display_Name

Papaverine

FDA_UNII_Code

DAA13NKG2Q

FULL_SYN

Papaverine

Pavabid

Pavacap

PAPAVERINE

Cerespan

Robaxapap

Pavatym

Cerebid

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C80006

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97985

label

Papaverine

Legacy_Concept_Name

Papaverine

NSC_Code

136630

PDQ_Closed_Trial_Search_ID

39545

PDQ_Open_Trial_Search_ID

39545

Preferred_Name

Papaverine

prefixIRI

ncit:C726

Semantic_Type

Pharmacologic Substance

Organic Chemical

UMLS_CUI

C0030350

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C744

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29707

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http://purl.bioontology.org/ontology/LNC/MTHU003466 LOINC LOOM
http://www.drugbank.ca/drugs/DB01113 FTC LOOM
http://www.co-ode.org/ontologies/galen#Papaverine GALEN LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Papaverine APAONTO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0030350 OCHV LOOM
https://bioportal.bioontology.org/ontologies/FTDM.owl#papaverine FASTO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.132.577.750 RH-MESH LOOM
http://purl.bioontology.org/ontology/UATC/A03AD01 ATC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.132.098.666 RH-MESH LOOM
http://purl.bioontology.org/ontology/UATC/G04BE02 ATC LOOM
http://purl.obolibrary.org/obo/dinto_DB01113 DINTO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372784001 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/LNC/LP18145-0 LOINC LOOM
http://purl.bioontology.org/ontology/VANDF/4019875 VANDF LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000147960 OCVDAE LOOM
http://stirdf.jst.go.jp/id/200907038181637649 IOBC LOOM
http://purl.bioontology.org/ontology/MESH/D010208 MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/7895 RXNORM LOOM
http://purl.bioontology.org/ontology/CSP/2530-5634 CRISP LOOM
http://purl.bioontology.org/ontology/SNMI/C-815D0 SNMI LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D010208 RH-MESH LOOM
http://purl.jp/bio/4/id/200906024866360289 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.531.085.666 RH-MESH LOOM
http://purl.obolibrary.org/obo/CHEBI_28241 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_28241 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_28241 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_28241 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_28241 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_28241 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_28241 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_28241 NIFSTD LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147960 NDFRT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#9243 OCHV LOOM
http://purl.bioontology.org/ontology/RCD/gh3.. RCD LOOM