National Cancer Institute Thesaurus

Last uploaded: February 4, 2019
Preferred Name

Eltrombopag

Synonyms

Eltrombopag

ELTROMBOPAG

eltrombopag

Definitions

An orally active thrombopoietin receptor agonist with megakaryopoiesis stimulating activity. Eltrombopag binds to and stimulates the platelet thrombopoietin receptor (TPO-R or CD110), a member of the hematopoietin receptor superfamily. Activation of TPO-R leads to the proliferation and differentiation of megakaryocytes, thereby increasing the production of blood platelets.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C71634

ALT_DEFINITION

The active ingredient in a drug used to treat chronic immune thrombocytopenic purpura (a condition in which platelets are destroyed by the immune system). It causes more platelets to be made in the bone marrow. It is also being studied in the treatment of low platelet counts caused by chemotherapy. It is a type of thrombopoietin receptor agonist.

CAS_Registry

496775-61-2

Chemical_Formula

C25H22N4O4

code

C71634

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

An orally active thrombopoietin receptor agonist with megakaryopoiesis stimulating activity. Eltrombopag binds to and stimulates the platelet thrombopoietin receptor (TPO-R or CD110), a member of the hematopoietin receptor superfamily. Activation of TPO-R leads to the proliferation and differentiation of megakaryocytes, thereby increasing the production of blood platelets.

Display_Name

Eltrombopag

FDA_UNII_Code

S56D65XJ9G

FULL_SYN

Eltrombopag

ELTROMBOPAG

eltrombopag

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62501

Has_Target

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17695

label

Eltrombopag

Legacy_Concept_Name

Eltrombopag_Base

Preferred_Name

Eltrombopag

prefixIRI

ncit:C71634

Semantic_Type

Pharmacologic Substance

Amino Acid, Peptide, or Protein

UMLS_CUI

C1831905

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C78275

Delete Subject Author Type Created
No notes to display