National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Foscarnet

Synonyms

Phosphonoformate

Phosphonoformic Acid

Phosphonocarboxylic Acid

Carboxyphosphonic Acid

FOSCARNET

Foscarnet

Definitions

A synthetic organic analog of inorganic pyrophosphate with activity against several types of viruses, but primarily used for the treatment of cytomegalovirus retinitis. Foscarnet selectively blocks the pyrophosphate binding site of virus-specific DNA polymerases at concentrations that do not affect cellular DNA polymerases. Because this agent crosses the blood brain barrier, it may be used in the treatment of viral infections of the central nervous system.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C71630

CAS_Registry

4428-95-9

CHEBI_ID

CHEBI:127780

Chemical_Formula

CH3O5P

code

C71630

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

CTRP

FDA

DEFINITION

A synthetic organic analog of inorganic pyrophosphate with activity against several types of viruses, but primarily used for the treatment of cytomegalovirus retinitis. Foscarnet selectively blocks the pyrophosphate binding site of virus-specific DNA polymerases at concentrations that do not affect cellular DNA polymerases. Because this agent crosses the blood brain barrier, it may be used in the treatment of viral infections of the central nervous system.

Display_Name

Foscarnet

FDA_UNII_Code

364P9RVW4X

FULL_SYN

Phosphonoformate

Phosphonoformic Acid

Phosphonocarboxylic Acid

Carboxyphosphonic Acid

FOSCARNET

Foscarnet

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1193

label

Foscarnet

Legacy Concept Name

Foscarnet_Base

Preferred_Name

Foscarnet

prefixIRI

Thesaurus:C71630

Semantic_Type

Organic Chemical

Pharmacologic Substance

UMLS_CUI

C0070895

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97453

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Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/RXNORM/33562 RXNORM LOOM
http://purl.obolibrary.org/obo/OMIT_0017630 OMIT LOOM
http://www.co-ode.org/ontologies/galen#Foscarnet GALEN LOOM
http://purl.bioontology.org/ontology/NDDF/006662 NDDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.241.081.018.677.250 RH-MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#14620 OCHV LOOM
http://purl.bioontology.org/ontology/RCD/x01Iw RCD LOOM
http://purl.bioontology.org/ontology/ATC/J05AD01 ATC LOOM
http://purl.bioontology.org/ontology/MESH/D017245 MESH LOOM
http://purl.bioontology.org/ontology/LNC/MTHU012422 LOINC LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148246 ODAE LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148246 KTAO LOOM
http://purl.jp/bio/4/id/200906028481776633 IOBC LOOM
http://purl.obolibrary.org/obo/NCIT_C71630 BERO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372902006 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/SNMI/C-55B90 SNMI LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0070895 OCHV LOOM
http://purl.bioontology.org/ontology/LNC/LP15700-5 LOINC LOOM
http://stirdf.jst.go.jp/id/200907063446146663 IOBC LOOM
http://www.phoc.org.cn/pmo/class/PMO_00016290 PMAPP-PMO LOOM
http://purl.obolibrary.org/obo/MESH_D017245 BERO LOOM
http://purl.bioontology.org/ontology/VANDF/4020530 VANDF LOOM
http://purl.bioontology.org/ontology/CSP/4000-0186 CRISP LOOM
https://github.com/sap218/ocimido/blob/master/ontology/ocimido.owl#OCIMIDO_00577 OCIMIDO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148246 NDFRT LOOM
https://go.drugbank.com/drugs/DB00529 MDM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D017245 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.705.429.875.500 RH-MESH LOOM