loading...| Preferred Name |
Fludrocortisone |
|
| Synonyms |
fludrocortisone FLUDROCORTISONE Fludrocortisone Florinef |
|
| Definitions |
A synthetic corticosteroid with antiinflammatory and antiallergic properties. Fludrocortisone is a mineralocorticoid receptor and glucocorticoid receptor agonist that binds to cytoplasmic receptors, translocates to the nucleus and subsequently initiates the transcription of glucocorticoid-responsive genes such as lipocortins to inhibit phospholipase A2. This prevents the release of arachidonic acid, a precursor to prostaglandins and leukotrienes, both important mediators in the pro-inflammatory response mechanism. In addition, this agent exerts its mineralocorticoid effect on the distal tubules and collecting ducts of the kidney by inducing permease, an enzyme that regulates Na+ permeability in cells, thereby enhancing Na+ reabsorption and water retention as well as increasing K+, H+ excretion. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C71629 |
|
| ALT_DEFINITION |
A synthetic corticosteroid. It is used to replace steroid hormones normally produced by the adrenal gland. |
|
| CAS_Registry |
127-31-1 |
|
| CHEBI_ID |
CHEBI:50885 |
|
| Chemical_Formula |
C21H29FO5 |
|
| code |
C71629 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA HemOnc |
|
| DEFINITION |
A synthetic corticosteroid with antiinflammatory and antiallergic properties. Fludrocortisone is a mineralocorticoid receptor and glucocorticoid receptor agonist that binds to cytoplasmic receptors, translocates to the nucleus and subsequently initiates the transcription of glucocorticoid-responsive genes such as lipocortins to inhibit phospholipase A2. This prevents the release of arachidonic acid, a precursor to prostaglandins and leukotrienes, both important mediators in the pro-inflammatory response mechanism. In addition, this agent exerts its mineralocorticoid effect on the distal tubules and collecting ducts of the kidney by inducing permease, an enzyme that regulates Na+ permeability in cells, thereby enhancing Na+ reabsorption and water retention as well as increasing K+, H+ excretion. |
|
| FDA_UNII_Code |
U0476M545B |
|
| FULL_SYN |
fludrocortisone FLUDROCORTISONE Fludrocortisone Florinef |
|
| Has_Salt_Form | ||
| label |
Fludrocortisone |
|
| Legacy Concept Name |
Fludrocortisone_Base |
|
| NSC Number |
11318 |
|
| Preferred_Name |
Fludrocortisone |
|
| prefixIRI |
Thesaurus:C71629 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0016280 |
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| subClassOf |