loading...| Preferred Name |
Omeprazole |
|
| Synonyms |
5-Methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridinyl)methyl)sulfinyl)-1H-benzimidazole H168/68 Losec OMEP OMEPRAZOLE Omeprazole Prilosec omeprazole |
|
| Definitions |
A benzimidazole with selective and irreversible proton pump inhibition activity. Omeprazole forms a stable disulfide bond with the sulfhydryl group of the hydrogen-potassium (H+ - K+) ATPase found on the secretory surface of parietal cells, thereby inhibiting the final transport of hydrogen ions (via exchange with potassium ions) into the gastric lumen and suppressing gastric acid secretion. This agent exhibits no anticholinergic activities and does not antagonize histamine H2 receptors. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C716 |
|
| ALT_DEFINITION |
A drug that inhibits gastric acid secretion. |
|
| CAS_Registry |
73590-58-6 |
|
| CHEBI_ID |
CHEBI:7772 |
|
| Chemical_Formula |
C17H19N3O3S |
|
| code |
C716 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 |
|
| Contributing_Source |
CTRP FDA HemOnc |
|
| DEFINITION |
A benzimidazole with selective and irreversible proton pump inhibition activity. Omeprazole forms a stable disulfide bond with the sulfhydryl group of the hydrogen-potassium (H+ - K+) ATPase found on the secretory surface of parietal cells, thereby inhibiting the final transport of hydrogen ions (via exchange with potassium ions) into the gastric lumen and suppressing gastric acid secretion. This agent exhibits no anticholinergic activities and does not antagonize histamine H2 receptors. |
|
| Display_Name |
Omeprazole |
|
| FDA_UNII_Code |
KG60484QX9 |
|
| FULL_SYN |
5-Methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridinyl)methyl)sulfinyl)-1H-benzimidazole H168/68 Losec OMEP OMEPRAZOLE Omeprazole Prilosec omeprazole |
|
| Has_Salt_Form | ||
| label |
Omeprazole |
|
| Legacy Concept Name |
Omeprazole |
|
| NCI_Drug_Dictionary_ID |
42309 |
|
| PDQ_Closed_Trial_Search_ID |
42309 |
|
| PDQ_Open_Trial_Search_ID |
42309 |
|
| Preferred_Name |
Omeprazole |
|
| prefixIRI |
Thesaurus:C716 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0028978 |
|
| subClassOf |