National Cancer Institute Thesaurus

Last uploaded: March 26, 2019
Preferred Name

Niacin

Synonyms

Niacin

NIACIN

Vitamin B3

nicotinic acid

vitamin B3

Nicotinic acid

niacin

Nicotinic Acid Amide

Nicotinic Acid

3-Pyridinecarboxylic Acid

Nicotinamide

Vitamin B-3

Definitions

A water-soluble vitamin belonging to the vitamin B family, which occurs in many animal and plant tissues, with antihyperlipidemic activity. Niacin is converted to its active form niacinamide, which is a component of the coenzymes nicotinamide adenine dinucleotide (NAD) and its phosphate form, NADP. These coenzymes play an important role in tissue respiration and in glycogen, lipid, amino acid, protein, and purine metabolism. Although the exact mechanism of action by which niacin lowers cholesterol is not fully understood, it may act by inhibiting the synthesis of very low density lipoproteins (VLDL), inhibiting the release of free fatty acids from adipose tissue, increasing lipoprotein lipase activity, and reducing the hepatic synthesis of VLDL-C and LDL-C.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C689

ALT_DEFINITION

Water-soluble vitamin that is a cosubstrate or coenzyme with numerous dehydrogenases for the transfer of the hydride ion. (DRI)

A nutrient in the vitamin B complex that the body needs in small amounts to function and stay healthy. Niacin helps some enzymes work properly and helps skin, nerves, and the digestive tract stay healthy. Niacin is found in many plant and animal products. It is water-soluble (can dissolve in water) and must be taken in every day. Not enough niacin can cause a disease called pellagra (a condition marked by skin, nerve, and digestive disorders). A form of niacin is being studied in the prevention of skin and other types of cancer. Niacin may help to lower blood cholesterol.

CAS_Registry

59-67-6

CHEBI_ID

CHEBI:15940

Chemical_Formula

C6H5NO2

code

C689

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799

Contributing_Source

CRCH

CTRP

FDA

DEFINITION

A water-soluble vitamin belonging to the vitamin B family, which occurs in many animal and plant tissues, with antihyperlipidemic activity. Niacin is converted to its active form niacinamide, which is a component of the coenzymes nicotinamide adenine dinucleotide (NAD) and its phosphate form, NADP. These coenzymes play an important role in tissue respiration and in glycogen, lipid, amino acid, protein, and purine metabolism. Although the exact mechanism of action by which niacin lowers cholesterol is not fully understood, it may act by inhibiting the synthesis of very low density lipoproteins (VLDL), inhibiting the release of free fatty acids from adipose tissue, increasing lipoprotein lipase activity, and reducing the hepatic synthesis of VLDL-C and LDL-C.

Display_Name

Niacin

FDA_UNII_Code

2679MF687A

FULL_SYN

Niacin

NIACIN

Vitamin B3

nicotinic acid

vitamin B3

Nicotinic acid

niacin

Nicotinic Acid Amide

Nicotinic Acid

3-Pyridinecarboxylic Acid

Nicotinamide

Vitamin B-3

INFOODS

NIA

label

Niacin

Legacy_Concept_Name

Niacin

Micronutrient

Y

NSC_Code

169454

Nutrient

Y

PDQ_Closed_Trial_Search_ID

38351

PDQ_Open_Trial_Search_ID

38351

Preferred_Name

Niacin

prefixIRI

ncit:C689

Semantic_Type

Organic Chemical

Vitamin

Tolerable_Level

Y

UMLS_CUI

C0027996

Unit

mg

US_Recommended_Intake

Y

USDA_ID

406

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C45812

Delete Subject Author Type Created
No notes to display
Create New Mapping

Delete Mapping To Ontology Source
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.066.515.475 RH-MESH LOOM
http://purl.bioontology.org/ontology/MESH/D009525 MESH LOOM
http://scai.fraunhofer.de/AlzheimerOntology#niactin ADO LOOM
http://www.semanticweb.org/ontologies/STO.owl#bf409857_b865_4976_b270_16084048f10a CVAO LOOM
http://www.semanticweb.org/ontologies/STO.owl#bf409857_b865_4976_b270_16084048f10a STO-DRAFT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.725.547.475 RH-MESH LOOM
http://id.loc.gov/authorities/subjects/sh85091698 FAST-TOPICAL LOOM
http://purl.bioontology.org/ontology/SNMI/F-BB430 SNMI LOOM
http://purl.bioontology.org/ontology/VANDF/4017661 VANDF LOOM
http://purl.bioontology.org/ontology/NDDF/001052 NDDF LOOM
http://purl.bioontology.org/ontology/RXNORM/7393 RXNORM LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/273943001 SNOMEDCT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D009525 RH-MESH LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000038351 PDQ LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005643 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005643 DMTO LOOM
http://www.drugbank.ca/drugs/DB00627 FTC LOOM
http://www.co-ode.org/ontologies/galen#Niacin GALEN LOOM
http://purl.bioontology.org/ontology/LNC/MTHU002113 LOINC LOOM
http://localhost/plosthes.2017-1#7772 PLOSTHES LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146039 NDFRT LOOM
http://purl.bioontology.org/ontology/MEDLINEPLUS/C0027996 MEDLINEPLUS LOOM
http://purl.bioontology.org/ontology/CSP/3147-2013 CRISP LOOM
http://purl.bioontology.org/ontology/LNC/LP14887-1 LOINC LOOM