National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Nivolumab

Synonyms

Nivolumab Biosimilar ABP 206

Nivolumab Biosimilar BCD-263

Nivolumab Biosimilar CMAB819

ABP 206

BCD-263

BMS-936558

CMAB819

MDX-1106

NIVO

NIVOLUMAB

Nivolumab

ONO-4538

Opdivo

Definitions

A fully human immunoglobulin (Ig) G4 monoclonal antibody directed against the negative immunoregulatory human cell surface receptor programmed death-1 (PD-1, PCD-1) with immune checkpoint inhibitory and antineoplastic activities. Upon administration, nivolumab binds to and blocks the activation of PD-1, an immunoglobulin superfamily (IgSF) transmembrane protein, by its ligands programmed cell death ligand 1 (PD-L1), which is overexpressed on certain cancer cells, and programmed cell death ligand 2 (PD-L2), which is primarily expressed on antigen-presenting cells (APCs). This results in the activation of T-cells and cell-mediated immune responses against tumor cells. Activated PD-1 negatively regulates T-cell activation and plays a key role in tumor evasion from host immunity.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C68814

Accepted_Therapeutic_Use_For

locally advanced or metastatic urothelial carcinoma; recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN); renal cell carcinoma (RCC) ; metastatic melanoma; non-small cell lung cancer (NSCLC); classical Hodgkin lymphoma (cHL); BRAF V600 wild-type, unresectable or metastatic melanoma; metastatic small cell lung cancer (SCLC) with progression after platinum-based chemotherapy and at least one other line of therapy.

CAS_Registry

946414-94-4

code

C68814

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186328

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186327

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186341

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537

Contributing_Source

CTRP

FDA

GDC

HemOnc

PCDC

DEFINITION

A fully human immunoglobulin (Ig) G4 monoclonal antibody directed against the negative immunoregulatory human cell surface receptor programmed death-1 (PD-1, PCD-1) with immune checkpoint inhibitory and antineoplastic activities. Upon administration, nivolumab binds to and blocks the activation of PD-1, an immunoglobulin superfamily (IgSF) transmembrane protein, by its ligands programmed cell death ligand 1 (PD-L1), which is overexpressed on certain cancer cells, and programmed cell death ligand 2 (PD-L2), which is primarily expressed on antigen-presenting cells (APCs). This results in the activation of T-cells and cell-mediated immune responses against tumor cells. Activated PD-1 negatively regulates T-cell activation and plays a key role in tumor evasion from host immunity.

Display_Name

Nivolumab

FDA_UNII_Code

31YO63LBSN

FULL_SYN

Nivolumab Biosimilar ABP 206

Nivolumab Biosimilar BCD-263

Nivolumab Biosimilar CMAB819

ABP 206

BCD-263

BMS-936558

CMAB819

MDX-1106

NIVO

NIVOLUMAB

Nivolumab

ONO-4538

Opdivo

Has_Target

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C94697

Is_Value_For_GDC_Property

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1909

label

Nivolumab

Legacy Concept Name

Anti-PD-1_Human_Monoclonal_Antibody_MDX-1106

Maps_To

Nivolumab

NCI_Drug_Dictionary_ID

539733

PDQ_Closed_Trial_Search_ID

539733

PDQ_Open_Trial_Search_ID

539733

Preferred_Name

Nivolumab

prefixIRI

Thesaurus:C68814

Semantic_Type

Amino Acid, Peptide, or Protein

Pharmacologic Substance

Immunologic Factor

UMLS_CUI

C3657270

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128037

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C129822

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