National Cancer Institute Thesaurus

Last uploaded: August 27, 2019
Preferred Name

Limonene

Synonyms

(4R)-1-methyl-4-prop-1-en-2-yl-cyclohexene

1-methyl-4-prop-1-en-2-yl-cyclohexene

Limonene

Definitions

An oral dietary supplement containing a natural cyclic monoterpene and major component of the oil extracted from citrus peels with potential chemopreventive and antitumor activities. Although the mechanism of action has yet to be fully elucidated, limonene and its metabolites perillic acid, dihydroperillic acid, uroterpenol and limonene 1,2-diol may inhibit tumor growth through inhibition of p21-dependent signaling and may induce apoptosis via the induction of the transforming growth factor beta-signaling pathway. In addition, they inhibit post-translational modification of signal transduction proteins, resulting in G1 cell cycle arrest as well as differential expression of cell cycle- and apoptosis-related genes.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C68543

Obsolete

true

ALT_DEFINITION

A terpene with two isoprene units forming a ring. The chemical structure is CC1=CCC(CC1)C(=C)C.

CAS_Registry

138-86-3

Chemical_Formula

C10H16

code

C68543

Concept_Status

Retired_Concept

Contributing_Source

CRCH

DEFINITION

An oral dietary supplement containing a natural cyclic monoterpene and major component of the oil extracted from citrus peels with potential chemopreventive and antitumor activities. Although the mechanism of action has yet to be fully elucidated, limonene and its metabolites perillic acid, dihydroperillic acid, uroterpenol and limonene 1,2-diol may inhibit tumor growth through inhibition of p21-dependent signaling and may induce apoptosis via the induction of the transforming growth factor beta-signaling pathway. In addition, they inhibit post-translational modification of signal transduction proteins, resulting in G1 cell cycle arrest as well as differential expression of cell cycle- and apoptosis-related genes.

deprecated

true

DesignNote

Tue Feb 28 12:22:20 EST 2012 - See 'DL-Limonene'

FULL_SYN

(4R)-1-methyl-4-prop-1-en-2-yl-cyclohexene

1-methyl-4-prop-1-en-2-yl-cyclohexene

Limonene

label

Limonene

Legacy_Concept_Name

Limonene

OLD_PARENT

Terpene

Preferred_Name

Limonene

prefixIRI

ncit:C68543

Semantic_Type

Pharmacologic Substance

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C104171

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http://purl.obolibrary.org/obo/CHEBI_15384 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_15384 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_15384 OCMR LOOM
http://purl.obolibrary.org/obo/CHEBI_15384 GO-PLUS LOOM
http://purl.bioontology.org/ontology/SNMI/C-31149 SNMI LOOM
http://purl.bioontology.org/ontology/RXNORM/1426777 RXNORM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C008281 RH-MESH LOOM
http://purl.obolibrary.org/obo/SIBO_0000223 SIBO LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000664042 PDQ LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/11038000 SNOMEDCT LOOM
http://purl.jp/bio/4/id/200906090981614033 IOBC LOOM
http://purl.obolibrary.org/obo/UPa_UPC06078 UPA LOOM
http://purl.bioontology.org/ontology/RXNORM/28730 RXNORM LOOM
http://purl.bioontology.org/ontology/RXNORM/1426476 RXNORM LOOM
http://purl.bioontology.org/ontology/RXNORM/1426477 RXNORM LOOM
http://purl.bioontology.org/ontology/RCD/X79EZ RCD LOOM
http://purl.bioontology.org/ontology/NDDF/007167 NDDF LOOM
http://stirdf.jst.go.jp/id/200907004949773006 IOBC LOOM
http://purl.jp/bio/4/id/200906023325459561 IOBC LOOM
http://stirdf.jst.go.jp/id/200907010163633715 IOBC LOOM
http://purl.obolibrary.org/obo/SIBO_0000359 SIBO LOOM
http://purl.obolibrary.org/obo/DRON_00015179 DRON LOOM
http://purl.bioontology.org/ontology/RXNORM/1363991 RXNORM LOOM
http://purl.bioontology.org/ontology/MESH/D000077222 MESH LOOM