National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Naproxen

Synonyms

d-2-(6-Methoxy-2-naphthyl)propionic Acid

6-Methoxy-alpha-methyl-2-naphthaleneacetic Acid

NAPROXEN

Naprosyn

Naproxen

RS-3540

naproxen

Definitions

A propionic acid derivative and a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic and analgesic activities. Naproxen inhibits the activity of the enzymes cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. The resulting decrease in prostaglandin synthesis is responsible for the therapeutic effects of naproxen. Naproxen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C680

ALT_DEFINITION

A drug used to treat mild pain and the symptoms of arthritis and several other conditions. It is also being studied in the treatment of bone pain in patients with cancer. Naprosyn stops the body from making substances that cause pain and inflammation. It is a type of nonsteroidal anti-inflammatory drug (NSAID) and a type of cyclooxygenase inhibitor.

CAS_Registry

22204-53-1

CHEBI_ID

CHEBI:7476

Chemical_Formula

C14H14O3

code

C680

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

CTRP

FDA

DEFINITION

A propionic acid derivative and a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic and analgesic activities. Naproxen inhibits the activity of the enzymes cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. The resulting decrease in prostaglandin synthesis is responsible for the therapeutic effects of naproxen. Naproxen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation.

Display_Name

Naproxen

FDA_UNII_Code

57Y76R9ATQ

FULL_SYN

d-2-(6-Methoxy-2-naphthyl)propionic Acid

6-Methoxy-alpha-methyl-2-naphthaleneacetic Acid

NAPROXEN

Naprosyn

Naproxen

RS-3540

naproxen

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C48006

label

Naproxen

Legacy Concept Name

Naproxen

NCI_Drug_Dictionary_ID

40222

PDQ_Closed_Trial_Search_ID

40222

PDQ_Open_Trial_Search_ID

40222

Preferred_Name

Naproxen

prefixIRI

Thesaurus:C680

Semantic_Type

Organic Chemical

Pharmacologic Substance

UMLS_CUI

C0700017

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1323

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Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/XCO_0001193 XCO LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000040222 PDQ LOOM
http://purl.bioontology.org/ontology/SNMI/C-60410 SNMI LOOM
http://purl.bioontology.org/ontology/VANDF/4018847 VANDF LOOM
https://bioportal.bioontology.org/ontologies/STMSO#Naproxen STMSO LOOM
http://www.phoc.org.cn/pmo/class/PMO_00016946 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372588000 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/ATC/M02AA12 ATC LOOM
http://purl.obolibrary.org/obo/NCIT_C680 BERO LOOM
http://purl.bioontology.org/ontology/RCD/j2c.. RCD LOOM
https://github.com/sap218/coid/blob/master/coid.owl#COID_00347 COID LOOM
http://scai.fraunhofer.de/AlzheimerOntology#naproxen ADO LOOM
http://bmi.utah.edu/ontologies/peontology/C0027396 RAO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.426.559.847.638.472.500 RH-MESH LOOM
http://purl.obolibrary.org/obo/CHEBI_7476 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_7476 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_7476 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_7476 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_7476 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_7476 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_7476 CHEBI LOOM
http://www.co-ode.org/ontologies/galen#Naproxen GALEN LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D009288 RH-MESH LOOM
http://purl.bioontology.org/ontology/LNC/LP16215-3 LOINC LOOM
http://purl.bioontology.org/ontology/ATC/G02CC02 ATC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147149 NDFRT LOOM
http://purl.bioontology.org/ontology/LNC/MTHU015374 LOINC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0027396 OCHV LOOM
http://purl.obolibrary.org/obo/OMIT_0010322 OMIT LOOM
https://go.drugbank.com/drugs/DB00788 MDM LOOM
http://purl.bioontology.org/ontology/MESH/D009288 MESH LOOM
http://purl.jp/bio/4/id/200906020191518869 IOBC LOOM
http://purl.bioontology.org/ontology/CSP/4001-0089 CRISP LOOM
http://purl.bioontology.org/ontology/RXNORM/7258 RXNORM LOOM
http://purl.bioontology.org/ontology/NDDF/002380 NDDF LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#8483 OCHV LOOM
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:03045 MIO LOOM
http://doe-generated-ontology.com/OntoAD#C0027396 ONTOAD LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.615.638.472.450 RH-MESH LOOM
http://purl.bioontology.org/ontology/ATC/M01AE02 ATC LOOM
http://stirdf.jst.go.jp/id/200907067016753227 IOBC LOOM
http://purl.obolibrary.org/obo/MESH_D009288 BERO LOOM
http://www.drugbank.ca/drugs/DB00788 FTC LOOM