Taxane-Pocket Binding Agent

Taxane-Site Binding Agent

Taxane-Pocket Binding Agent

Any of a class of anti-mitotic compounds that bind to the taxane site of the beta-tubulin subunit, a region described as a binding pocket located within the middle domain and corresponding to an approximate residue sequence of 217-231. Specifically, these agents bind to a cysteine residue within the pocket, which is also the binding site for GTP. Agents binding at the taxane site promote the polymerization of dimers to form a very rigid and stable microtubule structure which is not readily disassembled. By interfering with microtubule dynamics these agents inhibit the normal turnover process essential during mitosis, thereby causing cell-cycle arrest and/or apoptosis.

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C67437

C67437

Any of a class of anti-mitotic compounds that bind to the taxane site of the beta-tubulin subunit, a region described as a binding pocket located within the middle domain and corresponding to an approximate residue sequence of 217-231. Specifically, these agents bind to a cysteine residue within the pocket, which is also the binding site for GTP. Agents binding at the taxane site promote the polymerization of dimers to form a very rigid and stable microtubule structure which is not readily disassembled. By interfering with microtubule dynamics these agents inhibit the normal turnover process essential during mitosis, thereby causing cell-cycle arrest and/or apoptosis.

Taxane-Site Binding Agent

Taxane-Pocket Binding Agent

Taxane-Pocket Binding Agent

Taxane-Site_Binding_Agent

Taxane-Pocket Binding Agent

Thesaurus:C67437

Chemical Viewed Functionally

C1883268

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25974