National Cancer Institute Thesaurus

Last uploaded: October 28, 2019
Preferred Name

Barbiturate

Synonyms

Barbiturate

barbiturate

Definitions

A class of drugs characterized as central nervous system (CNS) depressants. Barbiturate compounds bind to the gamma amino butyric acid (GABA)-A receptor, thereby increasing the influx of chloride ions into the neuron and subsequently causing hyperpolarization, which produces a decrease in neuronal transmission. Other barbiturate effects in the CNS may include modulation of sodium and calcium channels as well as inhibition of glutamate-mediated excitation. Although the effects of barbiturates are seen throughout the CNS, the predominant effect occurs in the midbrain region, the part of the brain associated with arousal. CNS depressive effects associated with this drug class include mild sedation, hypnosis, anesthesia, and coma as well as a decrease in seizure activity.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C67084

ALT_DEFINITION

A drug used to treat insomnia, seizures, and convulsions, and to relieve anxiety and tension before surgery. It belongs to the family of drugs called central nervous system (CNS) depressants.

CHEBI_ID

CHEBI:22693

code

C67084

DEFINITION

A class of drugs characterized as central nervous system (CNS) depressants. Barbiturate compounds bind to the gamma amino butyric acid (GABA)-A receptor, thereby increasing the influx of chloride ions into the neuron and subsequently causing hyperpolarization, which produces a decrease in neuronal transmission. Other barbiturate effects in the CNS may include modulation of sodium and calcium channels as well as inhibition of glutamate-mediated excitation. Although the effects of barbiturates are seen throughout the CNS, the predominant effect occurs in the midbrain region, the part of the brain associated with arousal. CNS depressive effects associated with this drug class include mild sedation, hypnosis, anesthesia, and coma as well as a decrease in seizure activity.

FULL_SYN

Barbiturate

barbiturate

label

Barbiturate

Legacy_Concept_Name

Barbiturate

Preferred_Name

Barbiturate

prefixIRI

ncit:C67084

Semantic_Type

Chemical Viewed Functionally

UMLS_CUI

C0004745

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29756

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http://www.semanticweb.org/ontologies/STO.owl#OWLClass_bcd42ca4_3adf_4b93_bc2d_afdcb447c8e2 CVAO LOOM
http://www.semanticweb.org/ontologies/STO.owl#OWLClass_bcd42ca4_3adf_4b93_bc2d_afdcb447c8e2 STO-DRAFT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#21195 OCHV LOOM
http://www.projecthalo.com/aura#Barbiturate AURA LOOM
http://purl.obolibrary.org/obo/CHEBI_29745 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_29745 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_29745 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_29745 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_29745 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_29745 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_29745 NIFSTD LOOM
http://www.semanticweb.org/ontologies/STO.owl#OWLClass_60f85153_5af2_4b13_bfb9_0328198e336b CVAO LOOM
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http://www.gamuts.net/entity#barbiturate GAMUTS LOOM
http://purl.obolibrary.org/obo/CHEBI_22693 NIFSTD LOOM
http://purl.bioontology.org/ontology/RCD/X794r RCD LOOM
http://purl.bioontology.org/ontology/LNC/LA28414-3 LOINC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0004745 OCHV LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372798009 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/CSP/2517-5236 CRISP LOOM
http://d-nb.info/gnd/4144029-8 FAST-TOPICAL LOOM
http://purl.obolibrary.org/obo/UPa_UPC00813 UPA LOOM
http://purl.bioontology.org/ontology/LNC/LP16043-9 LOINC LOOM