National Cancer Institute Thesaurus

Last uploaded: October 28, 2019
Preferred Name

Thiopental Sodium

Synonyms

Pentothal

4,6(1H,5H)-Pyrimidinedione, 5-ethyldihydro-5-(1-methylbutyl)-2-thioxo-, Monosodium Salt

Sodium Penthiobarbital

THIOPENTAL SODIUM

Sodium Thiopental

Thiopental Sodium

Definitions

The sodium salt form of thiopental, an ultrashort-acting barbituric acid derivative, with anesthetic activity. Thiopental binds to the chloride ionophore site of the gamma-aminobutyric acid (GABA)-A/chloride ionophore receptor complex, thereby enhancing the inhibitory actions of GABA-A in the brain. This leads to synaptic inhibition, decreased neuronal excitability and induction of anesthesia. In addition, this agent decreases glutamate (Glu) responses.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66599

CAS_Registry

71-73-8

CHEBI_ID

CHEBI:9561

Chemical_Formula

C11H17N2O2S.Na

code

C66599

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

The sodium salt form of thiopental, an ultrashort-acting barbituric acid derivative, with anesthetic activity. Thiopental binds to the chloride ionophore site of the gamma-aminobutyric acid (GABA)-A/chloride ionophore receptor complex, thereby enhancing the inhibitory actions of GABA-A in the brain. This leads to synaptic inhibition, decreased neuronal excitability and induction of anesthesia. In addition, this agent decreases glutamate (Glu) responses.

FDA_UNII_Code

49Y44QZL70

FULL_SYN

Pentothal

4,6(1H,5H)-Pyrimidinedione, 5-ethyldihydro-5-(1-methylbutyl)-2-thioxo-, Monosodium Salt

Sodium Penthiobarbital

THIOPENTAL SODIUM

Sodium Thiopental

Thiopental Sodium

Has_Free_Acid_Or_Base_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C72166

label

Thiopental Sodium

Legacy_Concept_Name

Thiopental_Sodium

Preferred_Name

Thiopental Sodium

prefixIRI

ncit:C66599

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0936073

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C245

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C67084

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http://purl.jp/bio/4/id/200906092001138900 IOBC LOOM
http://purl.bioontology.org/ontology/NDDF/001398 NDDF LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387448009 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/CHEBI_9561 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_9561 OBIB LOOM
http://purl.obolibrary.org/obo/CHEBI_9561 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_9561 CHEBI LOOM
http://purl.bioontology.org/ontology/SNMI/C-6A176 SNMI LOOM
http://purl.bioontology.org/ontology/VANDF/4018713 VANDF LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147019 NDFRT LOOM
http://purl.bioontology.org/ontology/RXNORM/282416 RXNORM LOOM
http://psink.de/scio/ThiopentalSodium SCIO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0936073 OCHV LOOM
http://stirdf.jst.go.jp/id/200907029383294280 IOBC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#52840 OCHV LOOM