National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Silver Sulfadiazine

Synonyms

Silver Sulfadiazine

SILVER SULFADIAZINE

Sulfadiazine Silver

Flamazine

SSD

Silvadene

Sliverex

Thermazene

Definitions

A sulfonamide-based topical agent with antibacterial and antifungal activity. Silver sulfadiazine may act through a combination of the activity of silver and sulfadiazine. When this agent interacts with sodium chloride-containing body fluids, silver ions are released slowly and sustainably into wounded areas. Ionized silver atoms catalyze the formation of disulfide bonds leading to protein structural changes and inactivating thiol-containing enzymes; silver ions may also intercalate DNA thereby interfering with replication and transcription of bacteria. As a competitive inhibitor of para-aminobenzoic acid (PABA), sulfadiazine inhibits bacterial dihydropteroate synthase, thereby resulting in disruption of folic acid metabolism and ultimately DNA synthesis.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66567

CAS_Registry

22199-08-2

CHEBI_ID

CHEBI:9142

Chemical_Formula

C10H9N4O2S.Ag

code

C66567

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A sulfonamide-based topical agent with antibacterial and antifungal activity. Silver sulfadiazine may act through a combination of the activity of silver and sulfadiazine. When this agent interacts with sodium chloride-containing body fluids, silver ions are released slowly and sustainably into wounded areas. Ionized silver atoms catalyze the formation of disulfide bonds leading to protein structural changes and inactivating thiol-containing enzymes; silver ions may also intercalate DNA thereby interfering with replication and transcription of bacteria. As a competitive inhibitor of para-aminobenzoic acid (PABA), sulfadiazine inhibits bacterial dihydropteroate synthase, thereby resulting in disruption of folic acid metabolism and ultimately DNA synthesis.

FDA_UNII_Code

W46JY43EJR

FULL_SYN

Silver Sulfadiazine

SILVER SULFADIAZINE

Sulfadiazine Silver

Flamazine

SSD

Silvadene

Sliverex

Thermazene

Has_Free_Acid_Or_Base_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29468

label

Silver Sulfadiazine

Legacy Concept Name

Sulfadiazine_Silver

NCI_Drug_Dictionary_ID

717602

PDQ_Closed_Trial_Search_ID

717602

PDQ_Open_Trial_Search_ID

717602

Preferred_Name

Silver Sulfadiazine

prefixIRI

Thesaurus:C66567

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0037134

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29739

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28394

Delete Subject Author Type Created
No notes to display
Create mapping