Preferred Name |
Silver Sulfadiazine |
|
Synonyms |
Silver Sulfadiazine SILVER SULFADIAZINE Sulfadiazine Silver Flamazine SSD Silvadene Sliverex Thermazene |
|
Definitions |
A sulfonamide-based topical agent with antibacterial and antifungal activity. Silver sulfadiazine may act through a combination of the activity of silver and sulfadiazine. When this agent interacts with sodium chloride-containing body fluids, silver ions are released slowly and sustainably into wounded areas. Ionized silver atoms catalyze the formation of disulfide bonds leading to protein structural changes and inactivating thiol-containing enzymes; silver ions may also intercalate DNA thereby interfering with replication and transcription of bacteria. As a competitive inhibitor of para-aminobenzoic acid (PABA), sulfadiazine inhibits bacterial dihydropteroate synthase, thereby resulting in disruption of folic acid metabolism and ultimately DNA synthesis. |
|
ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66567 |
|
CAS_Registry |
22199-08-2 |
|
CHEBI_ID |
CHEBI:9142 |
|
Chemical_Formula |
C10H9N4O2S.Ag |
|
code |
C66567 |
|
Concept_In_Subset | ||
Contributing_Source |
FDA |
|
DEFINITION |
A sulfonamide-based topical agent with antibacterial and antifungal activity. Silver sulfadiazine may act through a combination of the activity of silver and sulfadiazine. When this agent interacts with sodium chloride-containing body fluids, silver ions are released slowly and sustainably into wounded areas. Ionized silver atoms catalyze the formation of disulfide bonds leading to protein structural changes and inactivating thiol-containing enzymes; silver ions may also intercalate DNA thereby interfering with replication and transcription of bacteria. As a competitive inhibitor of para-aminobenzoic acid (PABA), sulfadiazine inhibits bacterial dihydropteroate synthase, thereby resulting in disruption of folic acid metabolism and ultimately DNA synthesis. |
|
FDA_UNII_Code |
W46JY43EJR |
|
FULL_SYN |
Silver Sulfadiazine SILVER SULFADIAZINE Sulfadiazine Silver Flamazine SSD Silvadene Sliverex Thermazene |
|
Has_Free_Acid_Or_Base_Form | ||
label |
Silver Sulfadiazine |
|
Legacy Concept Name |
Sulfadiazine_Silver |
|
NCI_Drug_Dictionary_ID |
717602 |
|
PDQ_Closed_Trial_Search_ID |
717602 |
|
PDQ_Open_Trial_Search_ID |
717602 |
|
Preferred_Name |
Silver Sulfadiazine |
|
prefixIRI |
Thesaurus:C66567 |
|
Semantic_Type |
Pharmacologic Substance |
|
UMLS_CUI |
C0037134 |
|
subClassOf |