National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Olmesartan

Synonyms

OLMESARTAN

Olmesartan

Definitions

A synthetic imidazole derivative and angiotensin II receptor antagonist with antihypertensive activity. Olmesartan selectively binds to the angiotensin type 1 (AT1) receptor subtype in vascular smooth muscle and adrenal gland, thereby competing with angiotensin II for binding to the AT1 receptor. This prevents angiotensin II-induced vasoconstriction and interferes with angiotensin II-mediated aldosterone secretion, thereby decreasing aldosterone production and preventing aldosterone-stimulated sodium retention and potassium excretion.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66253

CAS_Registry

144689-24-7

CHEBI_ID

CHEBI:48416

Chemical_Formula

C24H26N6O3

code

C66253

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A synthetic imidazole derivative and angiotensin II receptor antagonist with antihypertensive activity. Olmesartan selectively binds to the angiotensin type 1 (AT1) receptor subtype in vascular smooth muscle and adrenal gland, thereby competing with angiotensin II for binding to the AT1 receptor. This prevents angiotensin II-induced vasoconstriction and interferes with angiotensin II-mediated aldosterone secretion, thereby decreasing aldosterone production and preventing aldosterone-stimulated sodium retention and potassium excretion.

FDA_UNII_Code

8W1IQP3U10

FULL_SYN

OLMESARTAN

Olmesartan

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47640

label

Olmesartan

Legacy Concept Name

Olmesartan

Preferred_Name

Olmesartan

prefixIRI

Thesaurus:C66253

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C1098320

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66930

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