Preferred Name |
Olmesartan |
|
Synonyms |
OLMESARTAN Olmesartan |
|
Definitions |
A synthetic imidazole derivative and angiotensin II receptor antagonist with antihypertensive activity. Olmesartan selectively binds to the angiotensin type 1 (AT1) receptor subtype in vascular smooth muscle and adrenal gland, thereby competing with angiotensin II for binding to the AT1 receptor. This prevents angiotensin II-induced vasoconstriction and interferes with angiotensin II-mediated aldosterone secretion, thereby decreasing aldosterone production and preventing aldosterone-stimulated sodium retention and potassium excretion. |
|
ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66253 |
|
CAS_Registry |
144689-24-7 |
|
CHEBI_ID |
CHEBI:48416 |
|
Chemical_Formula |
C24H26N6O3 |
|
code |
C66253 |
|
Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 |
|
Contributing_Source |
FDA |
|
DEFINITION |
A synthetic imidazole derivative and angiotensin II receptor antagonist with antihypertensive activity. Olmesartan selectively binds to the angiotensin type 1 (AT1) receptor subtype in vascular smooth muscle and adrenal gland, thereby competing with angiotensin II for binding to the AT1 receptor. This prevents angiotensin II-induced vasoconstriction and interferes with angiotensin II-mediated aldosterone secretion, thereby decreasing aldosterone production and preventing aldosterone-stimulated sodium retention and potassium excretion. |
|
FDA_UNII_Code |
8W1IQP3U10 |
|
FULL_SYN |
OLMESARTAN Olmesartan |
|
Has_Salt_Form | ||
label |
Olmesartan |
|
Legacy Concept Name |
Olmesartan |
|
Preferred_Name |
Olmesartan |
|
prefixIRI |
Thesaurus:C66253 |
|
Semantic_Type |
Pharmacologic Substance |
|
UMLS_CUI |
C1098320 |
|
subClassOf |