National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Netilmicin

Synonyms

NETILMICIN

Netilmicin

Definitions

A semisynthetic, water soluble aminoglycoside derived from sisomicin, a naturally occurring antibiotic produced by the fermentation of Micromonospora inyoensis. Netilmicin irreversibly binds to the 16S rRNA and S12 protein of the bacterial 30S ribosomal subunit. As a result, this agent interferes with the assembly of initiation complex between mRNA and the bacterial ribosome, thereby inhibiting the initiation of protein synthesis. In addition, netilmicin induces misreading of the mRNA template and causes translational frameshift, thereby results in premature termination. This eventually leads to bacterial cell death.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66236

CAS_Registry

56391-56-1

CHEBI_ID

CHEBI:7528

Chemical_Formula

C21H41N5O7

code

C66236

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A semisynthetic, water soluble aminoglycoside derived from sisomicin, a naturally occurring antibiotic produced by the fermentation of Micromonospora inyoensis. Netilmicin irreversibly binds to the 16S rRNA and S12 protein of the bacterial 30S ribosomal subunit. As a result, this agent interferes with the assembly of initiation complex between mRNA and the bacterial ribosome, thereby inhibiting the initiation of protein synthesis. In addition, netilmicin induces misreading of the mRNA template and causes translational frameshift, thereby results in premature termination. This eventually leads to bacterial cell death.

FDA_UNII_Code

4O5J85GJJB

FULL_SYN

NETILMICIN

Netilmicin

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66237

label

Netilmicin

Legacy Concept Name

Netilmicin

Preferred_Name

Netilmicin

prefixIRI

Thesaurus:C66236

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0027780

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2363

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Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/NDFRT/N0000147943 NDFRT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#8612 OCHV LOOM
http://purl.bioontology.org/ontology/MESH/D009428 MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/7337 RXNORM LOOM
http://purl.bioontology.org/ontology/SNMI/C-52560 SNMI LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D009428 RH-MESH LOOM
http://purl.obolibrary.org/obo/DRON_00011167 PDRO LOOM
http://purl.bioontology.org/ontology/ATC/J01GB07 ATC LOOM
http://purl.obolibrary.org/obo/OMIT_0010455 OMIT LOOM
http://purl.obolibrary.org/obo/ARO_0000038 ARO LOOM
http://purl.bioontology.org/ontology/LNC/LP16120-5 LOINC LOOM
http://stirdf.jst.go.jp/id/200907031348073993 IOBC LOOM
http://www.co-ode.org/ontologies/galen#Netilmicin GALEN LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0027780 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D09.408.051.374.785.525 RH-MESH LOOM
http://www.phoc.org.cn/pmo/class/PMO_00020955 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/RCD/e86.. RCD LOOM
http://purl.bioontology.org/ontology/ATC/S01AA23 ATC LOOM
http://purl.bioontology.org/ontology/VANDF/4019857 VANDF LOOM
http://purl.obolibrary.org/obo/dinto_DB00955 DINTO LOOM
http://purl.bioontology.org/ontology/LNC/MTHU008459 LOINC LOOM
http://purl.bioontology.org/ontology/NDDF/002785 NDDF LOOM
https://go.drugbank.com/drugs/DB00955 MDM LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387110005 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/MESH_D009428 BERO LOOM
http://purl.obolibrary.org/obo/NCIT_C66236 BERO LOOM
http://purl.jp/bio/4/id/200906081227632794 IOBC LOOM