National Cancer Institute Thesaurus

Last uploaded: September 30, 2019
Preferred Name

Doxepin

Synonyms

Doxepin

DOXEPIN

Silenor

Definitions

A dibenzoxepin derivative and tricyclic antidepressant (TCA) with antipruritic, antidepressive and anxiolytic activities. Doxepin blocks the reuptake of norepinephrine and serotonin (5-HT) into presynaptic terminals thereby prolonging the availability of the monoaminergic neurotransmitters within the synaptic cleft and enhancing their neurotransmission. Doxepin also has antagonistic effects on histamine H1, 5-HT2, alpha-1 adrenergic, and muscarinic receptors. The antipruritic effect of this agent is mediated through inhibition of histamine receptors.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C65475

Accepted_Therapeutic_Use_For

Insomnia

CAS_Registry

1668-19-5

CHEBI_ID

CHEBI:4710

code

C65475

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A dibenzoxepin derivative and tricyclic antidepressant (TCA) with antipruritic, antidepressive and anxiolytic activities. Doxepin blocks the reuptake of norepinephrine and serotonin (5-HT) into presynaptic terminals thereby prolonging the availability of the monoaminergic neurotransmitters within the synaptic cleft and enhancing their neurotransmission. Doxepin also has antagonistic effects on histamine H1, 5-HT2, alpha-1 adrenergic, and muscarinic receptors. The antipruritic effect of this agent is mediated through inhibition of histamine receptors.

FDA_UNII_Code

5ASJ6HUZ7D

FULL_SYN

Doxepin

DOXEPIN

Silenor

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29006

label

Doxepin

Legacy_Concept_Name

Doxepin

Preferred_Name

Doxepin

prefixIRI

ncit:C65475

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0013085

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C94727

Delete Subject Author Type Created
No notes to display
Create New Mapping

Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/RCD/d76.. RCD LOOM
http://purl.obolibrary.org/obo/dinto_DB01142 DINTO LOOM
http://purl.bioontology.org/ontology/LNC/MTHU004933 LOINC LOOM
http://stirdf.jst.go.jp/id/200907029433433945 IOBC LOOM
http://purl.bioontology.org/ontology/VANDF/4019736 VANDF LOOM
http://scai.fraunhofer.de/AlzheimerOntology#doxepin ADO LOOM
http://purl.bioontology.org/ontology/SNMI/C-62280 SNMI LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004270 FASTO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004270 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004270 DMTO LOOM
http://www.co-ode.org/ontologies/galen#Doxepin GALEN LOOM
http://purl.obolibrary.org/obo/CHEBI_4710 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_4710 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_4710 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_4710 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_4710 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_4710 NIFSTD LOOM
http://purl.bioontology.org/ontology/RXNORM/3638 RXNORM LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372587005 SNOMEDCT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D004316 RH-MESH LOOM
http://d-nb.info/gnd/4400401-1 FAST-TOPICAL LOOM
http://purl.bioontology.org/ontology/UATC/N06AA12 ATC LOOM
http://www.case.edu/EpSO.owl#Doxepin EPSO LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Doxepin APAONTO LOOM
http://purl.bioontology.org/ontology/MESH/D004316 MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#4103 OCHV LOOM
http://purl.bioontology.org/ontology/UATC/D04AX01 ATC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.355.291.852.500 RH-MESH LOOM
http://purl.jp/bio/4/id/200906058735186420 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.494.382.393 RH-MESH LOOM
http://purl.bioontology.org/ontology/LNC/LP14717-0 LOINC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0013085 OCHV LOOM
http://www.drugbank.ca/drugs/DB01142 FTC LOOM
http://purl.bioontology.org/ontology/NDDF/004607 NDDF LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147828 NDFRT LOOM