National Cancer Institute Thesaurus

Last uploaded: June 25, 2019
Preferred Name

Cefepime

Synonyms

Cefepime

cefepime

CEFEPIME

Definitions

A semisynthetic, broad-spectrum, fourth-generation cephalosporin with antibacterial activity. Cefepime binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C65294

ALT_DEFINITION

A drug used to treat infection. It belongs to the family of drugs called cephalosporin antibiotics.

CAS_Registry

88040-23-7

CHEBI_ID

CHEBI:478164

Chemical_Formula

C19H24N6O5S2

code

C65294

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A semisynthetic, broad-spectrum, fourth-generation cephalosporin with antibacterial activity. Cefepime binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.

FDA_UNII_Code

807PW4VQE3

FULL_SYN

Cefepime

cefepime

CEFEPIME

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1041

label

Cefepime

Legacy_Concept_Name

Cefepime_Base

Preferred_Name

Cefepime

prefixIRI

ncit:C65294

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0055003

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C357

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http://phenomebrowser.net/ontologies/mesh/mesh.owl#C043266 RH-MESH LOOM
http://purl.obolibrary.org/obo/CHEBI_478164 ODNAE LOOM
http://purl.obolibrary.org/obo/CHEBI_478164 GENEPIO LOOM
http://purl.obolibrary.org/obo/CHEBI_478164 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_478164 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_478164 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_478164 GENEPIO LOOM
http://purl.obolibrary.org/obo/CHEBI_478164 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_478164 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_478164 CHEBI LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/96048006 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/LNC/LP17165-9 LOINC LOOM
http://purl.bioontology.org/ontology/RXNORM/20481 RXNORM LOOM
http://purl.bioontology.org/ontology/LNC/MTHU008443 LOINC LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000022054 ODAE LOOM
http://purl.bioontology.org/ontology/VANDF/4024049 VANDF LOOM
http://purl.bioontology.org/ontology/NDDF/004974 NDDF LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000022054 NDFRT LOOM
http://purl.bioontology.org/ontology/MESH/D000077723 MESH LOOM
http://purl.bioontology.org/ontology/SNMI/C-53590 SNMI LOOM
http://purl.bioontology.org/ontology/UATC/J01DE01 ATC LOOM
http://purl.jp/bio/4/id/200906020386526823 IOBC LOOM
http://stirdf.jst.go.jp/id/200907005601174857 IOBC LOOM