loading...| Preferred Name |
Buclizine |
|
| Synonyms |
Aphilan-R Base Histabutizine 1-(p-tert-Butylbenzyl)-4-(4-chloro-alpha-phenylbenzyl)piperazine AH 2526 BUCLIZINE Buclizine Vibazine |
|
| Definitions |
A piperazine histamine H1 receptor antagonist with primarily antiemetic and antivertigo activities. Buclizine binds to and blocks the histamine H1 receptor, thereby preventing the symptoms that are caused by histamine activity. Buclizine exerts its anti-emetic effect by binding to and blocking the muscarinic and histamine receptors in the vomiting center of the central nervous system (CNS). This may prevent activation of the chemoreceptor trigger zone (CTZ) and may reduce nausea and vomiting. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C65273 |
|
| CAS_Registry |
82-95-1 |
|
| CHEBI_ID |
CHEBI:3205 |
|
| Chemical_Formula |
C28H33ClN2 |
|
| code |
C65273 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
A piperazine histamine H1 receptor antagonist with primarily antiemetic and antivertigo activities. Buclizine binds to and blocks the histamine H1 receptor, thereby preventing the symptoms that are caused by histamine activity. Buclizine exerts its anti-emetic effect by binding to and blocking the muscarinic and histamine receptors in the vomiting center of the central nervous system (CNS). This may prevent activation of the chemoreceptor trigger zone (CTZ) and may reduce nausea and vomiting. |
|
| FDA_UNII_Code |
0C94V6X681 |
|
| FULL_SYN |
Aphilan-R Base Histabutizine 1-(p-tert-Butylbenzyl)-4-(4-chloro-alpha-phenylbenzyl)piperazine AH 2526 BUCLIZINE Buclizine Vibazine |
|
| Has_Salt_Form | ||
| label |
Buclizine |
|
| Legacy Concept Name |
Buclizine |
|
| Preferred_Name |
Buclizine |
|
| prefixIRI |
Thesaurus:C65273 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0164386 |
|
| subClassOf |