loading...| Preferred Name |
Metolazone |
|
| Synonyms |
2-Methyl-3-o-tolyl-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone 7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide 7-Chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl-6-quinazolinesulfonamide Diulo METOLAZONE Metenix Metolazone Mykrox SR-720-22 Xuret Zaroxolyn |
|
| Definitions |
A long acting, quinazoline-based sulfonamide thiazide-like, diuretic. Similar to the thiazides, metolazone acts on the distal convoluted tubule (DCT) and inhibits the sodium-chloride symporter, thereby preventing sodium and chloride reabsorption and excretion of water. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C650 |
|
| CAS_Registry |
17560-51-9 |
|
| CHEBI_ID |
CHEBI:64354 |
|
| Chemical_Formula |
C16H16ClN3O3S |
|
| code |
C650 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
A long acting, quinazoline-based sulfonamide thiazide-like, diuretic. Similar to the thiazides, metolazone acts on the distal convoluted tubule (DCT) and inhibits the sodium-chloride symporter, thereby preventing sodium and chloride reabsorption and excretion of water. |
|
| FDA_UNII_Code |
TZ7V40X7VX |
|
| FULL_SYN |
2-Methyl-3-o-tolyl-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone 7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide 7-Chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl-6-quinazolinesulfonamide Diulo METOLAZONE Metenix Metolazone Mykrox SR-720-22 Xuret Zaroxolyn |
|
| label |
Metolazone |
|
| Legacy Concept Name |
Metolazone |
|
| Preferred_Name |
Metolazone |
|
| prefixIRI |
Thesaurus:C650 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0025854 |
|
| subClassOf |