loading...| Preferred Name |
Methylprednisolone |
|
| Synonyms |
(6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione Veriderm Medrol Methylprednisolone METHYLPREDNISOLONE Caberdelta M Depo-Nisolone Methylprednisolonum Predni-M-Tablinen Depo Moderin 6Alpha-Methylprednisolone DepMedalone methylprednisolone Medrol Veriderm Metilbetasone Solubile Sieropresol Adlone Duralone Emmetipi Esametone Firmacort Medlone 21 Medrate Medrol Medrone Mega-Star Meprolone Metrocort Metypresol Metysolon Prednilen Radilem Solpredone Summicort Urbason Wyacort |
|
| Definitions |
A synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone binds to and activates specific nuclear receptors, resulting in altered gene expression and inhibition of proinflammatory cytokine production. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cell populations. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C647 |
|
| Accepted_Therapeutic_Use_For |
Adrenocortical insufficiency; Conditions requiring immunosuppression; Inflammatory conditions; Multiple Sclerosis; Nephrotic syndrome |
|
| ALT_DEFINITION |
A corticosteroid hormone replacement. |
|
| CAS_Registry |
83-43-2 |
|
| CHEBI_ID |
CHEBI:6888 |
|
| Chemical_Formula |
C22H30O5 |
|
| code |
C647 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192234 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
CTRP FDA GDC HemOnc OORO |
|
| DEFINITION |
A synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone binds to and activates specific nuclear receptors, resulting in altered gene expression and inhibition of proinflammatory cytokine production. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cell populations. |
|
| Display_Name |
Methylprednisolone |
|
| FDA_UNII_Code |
X4W7ZR7023 |
|
| FULL_SYN |
(6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione Veriderm Medrol Methylprednisolone METHYLPREDNISOLONE Caberdelta M Depo-Nisolone Methylprednisolonum Predni-M-Tablinen Depo Moderin 6Alpha-Methylprednisolone DepMedalone methylprednisolone Medrol Veriderm Metilbetasone Solubile Sieropresol Adlone Duralone Emmetipi Esametone Firmacort Medlone 21 Medrate Medrol Medrone Mega-Star Meprolone Metrocort Metypresol Metysolon Prednilen Radilem Solpredone Summicort Urbason Wyacort |
|
| Has_Salt_Form |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C77422 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C87234 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C90955 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C48004 |
|
| Has_Target | ||
| Is_Value_For_GDC_Property | ||
| label |
Methylprednisolone |
|
| Legacy Concept Name |
Methylprednisolone |
|
| Maps_To |
Methylprednisolone |
|
| NCI_Drug_Dictionary_ID |
41528 |
|
| NSC Number |
19987 |
|
| PDQ_Closed_Trial_Search_ID |
41528 |
|
| PDQ_Open_Trial_Search_ID |
41528 |
|
| Preferred_Name |
Methylprednisolone |
|
| prefixIRI |
Thesaurus:C647 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0025815 |
|
| subClassOf |