National Cancer Institute Thesaurus

Last uploaded: October 28, 2019
Preferred Name

Methoxsalen

Synonyms

Metoxaleno

8-Methoxypsoralen

Uvadex

Meladinina

Oxsoralen-Ultra

Geralen

Mopsoralen

Geroxalen

Dermox

Oxsoralen

Methoxypsoralen

8-MOP

Ultramop

methoxsalen

Puvasoralen

Ammoidin

XANTHOTOXIN

9-Methoxy-7H-furo[3,2-g][1]benzopyran-7-one

Meladinine

Methoxsalen

Deltasoralen

METHOXSALEN

Xanthotoxin

Definitions

A naturally occurring substance isolated from the seeds of the plant Ammi majus with photoactivating properties. As a member of the family of compounds known as psoralens or furocoumarins, methoxsalen's exact mechanism of action is unknown; upon photoactivation, methoxsalen has been observed to bind covalently to and crosslink DNA. (NCI04)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C643

Accepted_Therapeutic_Use_For

Cutaneous T-cell lymphoma; psoriasis; vitiligo

ALT_DEFINITION

A drug used together with UV light to treat psoriasis, vitiligo, and skin nodules of cutaneous T-cell lymphoma. It is also being studied in the treatment of graft-versus-host disease. It belongs to the family of drugs called psoralens and furocoumarins.

CAS_Registry

298-81-7

CHEBI_ID

CHEBI:18358

Chemical_Formula

C12H8O4

code

C643

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

A naturally occurring substance isolated from the seeds of the plant Ammi majus with photoactivating properties. As a member of the family of compounds known as psoralens or furocoumarins, methoxsalen's exact mechanism of action is unknown; upon photoactivation, methoxsalen has been observed to bind covalently to and crosslink DNA. (NCI04)

Display_Name

Methoxsalen

FDA_UNII_Code

U4VJ29L7BQ

FULL_SYN

Metoxaleno

8-Methoxypsoralen

Uvadex

Meladinina

Oxsoralen-Ultra

Geralen

Mopsoralen

Geroxalen

Dermox

Oxsoralen

Methoxypsoralen

8-MOP

Ultramop

methoxsalen

Puvasoralen

Ammoidin

XANTHOTOXIN

9-Methoxy-7H-furo[3,2-g][1]benzopyran-7-one

Meladinine

Methoxsalen

Deltasoralen

METHOXSALEN

Xanthotoxin

label

Methoxsalen

Legacy_Concept_Name

Methoxsalen

NSC_Code

45923

PDQ_Closed_Trial_Search_ID

39499

PDQ_Open_Trial_Search_ID

39499

Preferred_Name

Methoxsalen

prefixIRI

ncit:C643

Semantic_Type

Pharmacologic Substance

Organic Chemical

UMLS_CUI

C0025684

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1420

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25760

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http://purl.bioontology.org/ontology/UATC/D05BA02 ATC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#8046 OCHV LOOM
http://purl.bioontology.org/ontology/MESH/D008730 MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/6854 RXNORM LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000039499 PDQ LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D008730 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.494.770.500 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.150.446.794.500 RH-MESH LOOM
http://purl.obolibrary.org/obo/CHEBI_18358 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_18358 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_18358 OCMR LOOM
http://purl.obolibrary.org/obo/CHEBI_18358 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_18358 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_18358 NIFSTD LOOM
http://purl.bioontology.org/ontology/UATC/D05AD02 ATC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147183 NDFRT LOOM
http://purl.bioontology.org/ontology/LNC/LP18383-7 LOINC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU004185 LOINC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0025684 OCHV LOOM
http://purl.bioontology.org/ontology/NDDF/002018 NDDF LOOM
http://purl.obolibrary.org/obo/DRON_00014318 DRON LOOM
http://purl.bioontology.org/ontology/VANDF/4018889 VANDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.830.219.446.794.500 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNMI/C-92820 SNMI LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/41062004 SNOMEDCT LOOM