National Cancer Institute Thesaurus

Last uploaded: June 25, 2019
Preferred Name

Methimazole

Synonyms

Tapazole

Methimazole

METHIMAZOLE

Definitions

A thioamide inhibitor of the enzyme thyroid peroxidase (TPO), with antithyroid activity. Upon administration, methimazole inhibits the metabolism of iodide and the iodination of tyrosine residues in the thyroid hormone precursor thyroglobulin by TPO; this prevents the synthesis of the thyroid hormones triiodothyronine (T3) and thyroxine (T4).

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C641

CAS_Registry

60-56-0

CHEBI_ID

CHEBI:50673

Chemical_Formula

C4H6N2S

code

C641

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

A thioamide inhibitor of the enzyme thyroid peroxidase (TPO), with antithyroid activity. Upon administration, methimazole inhibits the metabolism of iodide and the iodination of tyrosine residues in the thyroid hormone precursor thyroglobulin by TPO; this prevents the synthesis of the thyroid hormones triiodothyronine (T3) and thyroxine (T4).

Display_Name

Methimazole

FDA_UNII_Code

554Z48XN5E

FULL_SYN

Tapazole

Methimazole

METHIMAZOLE

label

Methimazole

Legacy_Concept_Name

Methimazole

NSC_Code

38608

PDQ_Closed_Trial_Search_ID

39287

PDQ_Open_Trial_Search_ID

39287

Preferred_Name

Methimazole

prefixIRI

ncit:C641

Semantic_Type

Pharmacologic Substance

Organic Chemical

UMLS_CUI

C0025644

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C885

Delete Subject Author Type Created
No notes to display
Create New Mapping

Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/LNC/LP18583-2 LOINC LOOM
http://www.drugbank.ca/drugs/DB00763 FTC LOOM
http://purl.bioontology.org/ontology/NDDF/002139 NDDF LOOM
http://purl.jp/bio/4/id/200906010569453196 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.489.600 RH-MESH LOOM
http://purl.bioontology.org/ontology/LNC/MTHU004698 LOINC LOOM
http://purl.bioontology.org/ontology/VANDF/4017434 VANDF LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000145822 NDFRT LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/37656002 SNOMEDCT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D008713 RH-MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/6835 RXNORM LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000145822 ODAE LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000039287 PDQ LOOM
http://purl.bioontology.org/ontology/MESH/D008713 MESH LOOM
http://purl.obolibrary.org/obo/CHEBI_50673 ODNAE LOOM
http://purl.obolibrary.org/obo/CHEBI_50673 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_50673 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_50673 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_50673 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_50673 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_50673 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_50673 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_50673 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_50673 HINO LOOM
http://purl.obolibrary.org/obo/CHEBI_50673 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_50673 NIFSTD LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.129.308.535 RH-MESH LOOM