loading...| Preferred Name |
Megestrol |
|
| Synonyms |
Compound 5071 Pregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl- MEG MEGESTROL Megestrol megestrol |
|
| Definitions |
A synthetic derivative of progesterone with antiestrogenic activity. Megestrol binds to and activates nuclear receptors which subsequently bind to and activate target genes for transcription. As an antiestrogen, this agent may inhibit the growth-stimulating effects of estrogen on estrogen-sensitive tumor cells. In addition, megestrol stimulates appetite in cachectic subjects. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C630 |
|
| Accepted_Therapeutic_Use_For |
Anorexia; breast and endometrial carcinoma, palliative; cachexia |
|
| ALT_DEFINITION |
A drug used to block estrogen and suppress the effects of estrogen and androgens. It is used to treat breast and endometrial cancer, and is being studied in the treatment of other types of cancer. It is also used to improve appetite in patients with cancer. Megestrol belongs to the group of hormones called progestins. |
|
| CAS_Registry |
3562-63-8 |
|
| CHEBI_ID |
CHEBI:6722 |
|
| Chemical_Formula |
C22H30O3 |
|
| code |
C630 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 |
|
| Contributing_Source |
CTRP FDA HemOnc |
|
| DEFINITION |
A synthetic derivative of progesterone with antiestrogenic activity. Megestrol binds to and activates nuclear receptors which subsequently bind to and activate target genes for transcription. As an antiestrogen, this agent may inhibit the growth-stimulating effects of estrogen on estrogen-sensitive tumor cells. In addition, megestrol stimulates appetite in cachectic subjects. |
|
| Display_Name |
Megestrol |
|
| FDA_UNII_Code |
EA6LD1M70M |
|
| FULL_SYN |
Compound 5071 Pregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl- MEG MEGESTROL Megestrol megestrol |
|
| Has_Salt_Form | ||
| Has_Target | ||
| label |
Megestrol |
|
| Legacy Concept Name |
Megestrol |
|
| Preferred_Name |
Megestrol |
|
| prefixIRI |
Thesaurus:C630 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0025175 |
|
| subClassOf |