loading...| Preferred Name |
Mechlorethamine Hydrochloride |
|
| Synonyms |
Chlorethazine Hydrochloride Mustine hydrochloride Methylbis(beta-chloroethyl)amine Hydrochloride Chloromethine HCl Mechlorethamine hydrochloride Chlormethine hydrochloride Mustargen Hydrochloride Methylchlorethamine Hydrochloride Chlorethamine HCl Chloromethine Hydrochloride Mustargen HCl Onco-Cloramin mechlorethamine HCl ethanamine,2-chloro-N-(2-chloroethyl)-N-methyl Hydrochloride Bis(2-chloroethyl)methylamine Hydrochloride Mechlorethamine Hydrochloride MECHLORETHAMINE HYDROCHLORIDE HN 2 Hydrochloride Caryolysine Chlormethine Hydrochloride Mustine Hydrochloride mechlorethamine hydrochloride chlorethamine hydrochloride Mustargen hydrochloride Cloramin Erasol Mustargen N-Lost WR-147650 mustine |
|
| Definitions |
The hydrochloride salt of mechlorethamine, a nitrogen mustard and an analogue of sulfur mustard, with antineoplastic and immunosuppressive activities. Mechlorethamine is metabolized to an unstable, highly reactive ethyleniminium intermediate that alkylates DNA, particularly the 7 nitrogen of guanine residues, resulting in DNA base pair mismatching, DNA interstrand crosslinking, the inhibition of DNA repair and synthesis, cell-cycle arrest, and apoptosis. This agent also exhibits lympholytic properties. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C627 |
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| Accepted_Therapeutic_Use_For |
Bronchogenic carcinoma; chronic lymphocytic and myelcytic leukemia; Hodgkins dieseas, palliative; lymphosarcoma; mycosis fungoides; polycythemia vera |
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| ALT_DEFINITION |
A drug used to treat some types of cancer and some skin conditions that may become cancer. It attaches to the cell's DNA and may kill cancer cells. Mechlorethamine hydrochloride is a type of alkylating agent. |
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| CAS_Registry |
55-86-7 |
|
| CHEBI_ID |
CHEBI:55368 |
|
| Chemical_Formula |
C5H11Cl2N.HCl |
|
| code |
C627 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
CTRP FDA GDC |
|
| DEFINITION |
The hydrochloride salt of mechlorethamine, a nitrogen mustard and an analogue of sulfur mustard, with antineoplastic and immunosuppressive activities. Mechlorethamine is metabolized to an unstable, highly reactive ethyleniminium intermediate that alkylates DNA, particularly the 7 nitrogen of guanine residues, resulting in DNA base pair mismatching, DNA interstrand crosslinking, the inhibition of DNA repair and synthesis, cell-cycle arrest, and apoptosis. This agent also exhibits lympholytic properties. |
|
| Display_Name |
Mechlorethamine Hydrochloride |
|
| FDA_UNII_Code |
L0MR697HHI |
|
| FULL_SYN |
Chlorethazine Hydrochloride Mustine hydrochloride Methylbis(beta-chloroethyl)amine Hydrochloride Chloromethine HCl Mechlorethamine hydrochloride Chlormethine hydrochloride Mustargen Hydrochloride Methylchlorethamine Hydrochloride Chlorethamine HCl Chloromethine Hydrochloride Mustargen HCl Onco-Cloramin mechlorethamine HCl ethanamine,2-chloro-N-(2-chloroethyl)-N-methyl Hydrochloride Bis(2-chloroethyl)methylamine Hydrochloride Mechlorethamine Hydrochloride MECHLORETHAMINE HYDROCHLORIDE HN 2 Hydrochloride Caryolysine Chlormethine Hydrochloride Mustine Hydrochloride mechlorethamine hydrochloride chlorethamine hydrochloride Mustargen hydrochloride Cloramin Erasol Mustargen N-Lost WR-147650 mustine |
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| Has_Free_Acid_Or_Base_Form | ||
| Is_Value_For_GDC_Property | ||
| label |
Mechlorethamine Hydrochloride |
|
| Legacy Concept Name |
Nitrogen_Mustard |
|
| Maps_To |
Mechlorethamine Hydrochloride |
|
| NCI_Drug_Dictionary_ID |
43434 |
|
| NSC Number |
762 |
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| PDQ_Closed_Trial_Search_ID |
43434 |
|
| PDQ_Open_Trial_Search_ID |
43434 |
|
| Preferred_Name |
Mechlorethamine Hydrochloride |
|
| prefixIRI |
Thesaurus:C627 |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0600266 |
|
| subClassOf |