National Cancer Institute Thesaurus

Last uploaded: May 28, 2019
Preferred Name

Recombinant Parathyroid Hormone

Synonyms

Recombinant Parathyroid Hormone

PARATHYROID HORMONE

Definitions

A recombinant therapeutic agent that is identical or similar to an 84-amino-acid polypeptide produced by the parathyroid gland which functions to maintain a constant concentration of calcium ions (Ca2+) in the extracellular fluid. In target tissues, parathyroid hormone (PTH) binds to and activates the PTH receptor (PTHR), a cell surface G protein-coupled receptor; there are two types of receptors, PTHR1 found in bone and the kidney and PTHR2 found primarily in the central nervous system (CNS), pancreas, testis, and placenta. Activation of PTHRs results in the activation of adenylyl cyclase and phospholipase C in target tissue cells, which, depending upon the specific target tissue, results in the enhancement of intestinal Ca2+ absorption, mobilization of bone Ca2+, and renal Ca2+ reabsorption.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62555

CAS_Registry

9002-64-6

code

C62555

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

A recombinant therapeutic agent that is identical or similar to an 84-amino-acid polypeptide produced by the parathyroid gland which functions to maintain a constant concentration of calcium ions (Ca2+) in the extracellular fluid. In target tissues, parathyroid hormone (PTH) binds to and activates the PTH receptor (PTHR), a cell surface G protein-coupled receptor; there are two types of receptors, PTHR1 found in bone and the kidney and PTHR2 found primarily in the central nervous system (CNS), pancreas, testis, and placenta. Activation of PTHRs results in the activation of adenylyl cyclase and phospholipase C in target tissue cells, which, depending upon the specific target tissue, results in the enhancement of intestinal Ca2+ absorption, mobilization of bone Ca2+, and renal Ca2+ reabsorption.

Display_Name

Recombinant Parathyroid Hormone

FDA_UNII_Code

N19A0T0E5J

FULL_SYN

Recombinant Parathyroid Hormone

PARATHYROID HORMONE

Has_Target

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C12568

label

Recombinant Parathyroid Hormone

Legacy_Concept_Name

Recombinant_Parathyroid_Hormone

PDQ_Closed_Trial_Search_ID

489119

PDQ_Open_Trial_Search_ID

489119

Preferred_Name

Recombinant Parathyroid Hormone

prefixIRI

ncit:C62555

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C1882913

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C548

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http://purl.bioontology.org/ontology/SNOMEDCT/428295002 SNOMEDCT LOOM