National Cancer Institute Thesaurus

Last uploaded: October 28, 2019
Preferred Name

Mannitol

Synonyms

D-Mannitol

Mannitol

MANNITOL

Osmitrol

Mannitol, D-

Resectisol

mannitol

Definitions

A naturally occurring alcohol found in fruits and vegetables and used as an osmotic diuretic. Mannitol is freely filtered by the glomerulus and poorly reabsorbed from the renal tubule, thereby causing an increase in osmolarity of the glomerular filtrate. An increase in osmolarity limits tubular reabsorption of water and inhibits the renal tubular reabsorption of sodium, chloride, and other solutes, thereby promoting diuresis. In addition, mannitol elevates blood plasma osmolarity, resulting in enhanced flow of water from tissues into interstitial fluid and plasma.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C625

ALT_DEFINITION

A drug used to decrease swelling of the brain and to treat kidney failure. Mannitol can also be used to open the blood-brain barrier, which allows anticancer medicines to enter the brain and treat brain tumors.

CAS_Registry

69-65-8

CHEBI_ID

CHEBI:16899

Chemical_Formula

C6H14O6

code

C625

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

A naturally occurring alcohol found in fruits and vegetables and used as an osmotic diuretic. Mannitol is freely filtered by the glomerulus and poorly reabsorbed from the renal tubule, thereby causing an increase in osmolarity of the glomerular filtrate. An increase in osmolarity limits tubular reabsorption of water and inhibits the renal tubular reabsorption of sodium, chloride, and other solutes, thereby promoting diuresis. In addition, mannitol elevates blood plasma osmolarity, resulting in enhanced flow of water from tissues into interstitial fluid and plasma.

Display_Name

Mannitol

FDA_UNII_Code

3OWL53L36A

FULL_SYN

D-Mannitol

Mannitol

MANNITOL

Osmitrol

Mannitol, D-

Resectisol

mannitol

label

Mannitol

Legacy_Concept_Name

Mannitol

NSC_Code

407017

PDQ_Closed_Trial_Search_ID

39493

PDQ_Open_Trial_Search_ID

39493

Preferred_Name

Mannitol

prefixIRI

ncit:C625

Semantic_Type

Pharmacologic Substance

Organic Chemical

UMLS_CUI

C0024730

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C49187

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http://purl.bioontology.org/ontology/SNMI/C-72050 SNMI LOOM
http://www.ifomis.org/acgt/1.0#Mannitol ACGT-MO LOOM
http://localhost/plosthes.2017-1#401 PLOSTHES LOOM
http://www.semanticweb.org/ontologies/STO.owl#OWLClass_1261b236_647b_4511_a82f_1e93dfce2b86 CVAO LOOM
http://www.semanticweb.org/ontologies/STO.owl#OWLClass_1261b236_647b_4511_a82f_1e93dfce2b86 STO-DRAFT LOOM
http://purl.bioontology.org/ontology/LNC/MTHU015736 LOINC LOOM
https://bioportal.bioontology.org/ontologies/FTDM.owl#mannitol FASTO LOOM
http://purl.bioontology.org/ontology/VANDF/4017741 VANDF LOOM
http://purl.bioontology.org/ontology/UATC/B05CX04 ATC LOOM
http://purl.bioontology.org/ontology/UATC/A06AD16 ATC LOOM
http://purl.bioontology.org/ontology/UATC/B05BC01 ATC LOOM
http://purl.bioontology.org/ontology/MESH/D008353 MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D008353 RH-MESH LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000039493 PDQ LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387168006 SNOMEDCT LOOM
http://purl.jp/bio/4/id/200906023831021833 IOBC LOOM
http://stirdf.jst.go.jp/id/200907040931033150 IOBC LOOM
http://purl.bioontology.org/ontology/NDDF/002272 NDDF LOOM
http://purl.jp/bio/10/gmo/GMO_001135 GMO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146108 NDFRT LOOM
http://www.co-ode.org/ontologies/galen#Mannitol GALEN LOOM
http://purl.bioontology.org/ontology/CSP/2828-5241 CRISP LOOM
http://purl.bioontology.org/ontology/RCD/XM0l6 RCD LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0024730 OCHV LOOM
http://purl.bioontology.org/ontology/RXNORM/6628 RXNORM LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#7731 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D09.853.609 RH-MESH LOOM
http://purl.obolibrary.org/obo/CHEBI_29864 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_29864 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_29864 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_29864 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_29864 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_29864 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_29864 MCO LOOM
http://purl.obolibrary.org/obo/CHEBI_29864 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_29864 PECO LOOM
http://purl.obolibrary.org/obo/CHEBI_29864 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_29864 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_29864 NIFSTD LOOM
http://purl.bioontology.org/ontology/LNC/LP173649-7 LOINC LOOM
http://purl.bioontology.org/ontology/UATC/R05CB16 ATC LOOM
http://www.semanticweb.org/tome/ontologies/2015/7/Richfields#mannitol ISO-FOOD LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.033.800.609 RH-MESH LOOM
http://purl.bioontology.org/ontology/LNC/LP15722-9 LOINC LOOM